Mid-term outcomes of laparoscopic vs open colectomy for pathological T4 and/or N2 colon cancer patients: Multicenter study using propensity score matched analysis

被引：1

作者：

Hashimoto, Shintaro ^{[1
]}

Tominaga, Tetsuro ^{[1
,7
]}

Nonaka, Takashi ^{[1
]}

Shiraishi, Toshio ^{[1
]}

To, Kazuo ^{[2
]}

Takeshita, Hiroaki ^{[3
]}

Fukuoka, Hidetoshi ^{[4
]}

Araki, Masato ^{[5
]}

Tanaka, Kenji ^{[6
]}

Sawai, Terumitsu ^{[1
]}

Nagayasu, Takeshi ^{[1
]}

机构：

[1] Nagasaki Univ, Dept Surg Oncol, Grad Sch Biomed Sci, Nagasaki, Japan

[2] Natl Hosp Org Ureshino Med Ctr, Dept Surg, Ureshino, Japan

[3] Natl Hosp Org Nagasaki Med Ctr, Dept Surg, Ohmura, Japan

[4] Isahaya Gen Hosp, Dept Surg, Isahaya, Japan

[5] Sasebo City Gen Hosp, Dept Surg, Sasebo, Japan

[6] Saiseikai Nagasaki Hosp, Dept Surg, Nagasaki, Japan

[7] Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg Oncol, 1-7-1 Sakamoto, Nagasaki 8528501, Japan

来源：

ASIAN JOURNAL OF ENDOSCOPIC SURGERY | 2023年 / 16卷 / 03期

关键词：

colon cancer; laparoscopic surgery; mid-term outcomes; RANDOMIZED CONTROLLED-TRIAL; SHORT-TERM OUTCOMES; OPEN SURGERY; COLORECTAL-CANCER; MULTIVISCERAL RESECTION; ADJUVANT CHEMOTHERAPY; ONCOLOGICAL OUTCOMES; STAGE-II; SURVIVAL; OPERATION;

D O I：

10.1111/ases.13171

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objectives: We aimed to assess mid-term outcomes after laparoscopic surgery (LAP) vs open surgery (OP) for pathological T4 (pT4) and/or N2 (pN2) colon cancer.Methods: We retrospectively reviewed 255 primary tumor resections for pT4 and/or pN2 colon cancer performed from 2015 to 2020 at six hospitals, divided into LAP (n = 204) and OP groups (n = 51). After propensity score matching to minimize selection bias, 47 matched patients per group were assessed. Results: Before matching, the rate of males (53.9% vs. 37.3%, P = .042), left sided colon cancer (53.9% vs 37.3%, P = .042), D3 lymph node dissection (90.7% vs 68.6%, P < .001) and body mass index (kg/m2) (22.3 vs 21.8, P = .039) were significantly greater in the LAP group. The rate of pT4b (7.8% vs 40.4%, P < .001) was lower and pN2 was higher (57.4% vs 37.3%, P = .012) in the LAP group. After matching, preoperative characteristics and pathologic status were equivalent between the groups. The LAP and OP groups showed comparable overall survival (OS) (2-year OS, 84.5% vs 76.8%, P = .055) and recurrence-free survival (RFS) (2-year RFS, 73.9% vs 52.8%, P = .359). In the patients with pT4, OS (2-year OS, 79.4% vs 75.7%, P = .359) and RFS (2-year RFS, 71.3% vs 58.7%) were comparable. In the patients with pN2, OS (2-year OS, 83.4% vs 76.3%) and RFS (2-year RFS, 69.6% vs 36.2%) were also comparable.Conclusions: LAP for pT4 and/or pN2 colon cancer showed comparable mid-term outcomes compared with OP. LAP was an acceptable surgical approach in this cohort.

引用

页码：400 / 408

页数：9

共 43 条

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