Synthesis of Quercetin-Acid Esters and Its Reduction of H2O2-Triggered PC12 Cells Damage by Down-Regulating ROS

被引：0

作者：

Li, Jian-Wen ^{[1
]}

Zhang, Wen-Cheng ^{[1
]}

Wu, Ze-Yu ^{[1
]}

Liu, Hao ^{[1
]}

Wang, Yun-Chun ^{[1
]}

Liu, Qing-Song ^{[1
]}

Li, Sheng-Nan ^{[1
]}

Lin, Yan-Ting ^{[1
]}

Hui, Ai-Ling ^{[1
]}

机构：

[1] Hefei Univ Technol, Engn Res Ctr Bioproc, Sch Food & Biol Engn, Minist Educ, 420 Feicui Rd, Hefei 230001, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 02期

关键词：

quercetin; anti-oxidation; radical reactions; apoptosis; fluorescent probes; ANTIOXIDANT; DERIVATIVES;

D O I：

10.1002/cbdv.202200897

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quercetin is a kind of polyphenolic flavonoid compounds which has perfect antioxidant properties. However, quercetin is not available in many situations due to its poor bioavailability. In this work, the QAEs with better solubility and even stronger antioxidant properties were synthesized, through the esterification between quercetin and the chlorinated cinnamic acid or its derivatives, whose chlorination were achieved by using SOCl2. The protective effects of the QAEs were evaluated by the H2O2-induced apoptosis experiment in rat adrenal pheochromocytoma cells (PC12 cells) and its ability to remove ROS generated by oxidative stress. Compared with the original quercetin group, the QAEs groups showed much improved cell viability and capability of removing ROS, which means their higher bioavailability than the parent.

引用

页数：9

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