The chemical constituents from twigs of Hamamelis japonica and their antiviral activities

被引：1

作者：

Park, SeonJu ^{[1
]}

Nguyen Xuan Nhiem ^{[2
]}

Song, Jae-Hyoung ^{[3
]}

Oh, Mira ^{[4
]}

Kim, Kil-Nam ^{[1
]}

Ko, Hyun-Jeong ^{[3
]}

Kim, Seung Hyun ^{[4
]}

机构：

[1] Korea Basic Sci Inst KBSI, Chuncheon Ctr, Chunchon, South Korea

[2] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

[3] Kangwon Natl Univ, Coll Pharm, Lab Microbiol & Immunol, Chunchon, South Korea

[4] Yonsei Univ, Coll Pharm, Yonsei Inst Pharmaceut Sci, Incheon, South Korea

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Hamamelis japonica; Hamamelidaceae; monoterpenoid glycosides; flavanol; antiviral activities; GLYCOSIDES; DERIVATIVES; GLUCOSIDE; TANNINS;

D O I：

10.1080/14786419.2022.2094376

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new monoterpenoid glycosides (1-3) and one new flavanol (4) along with 15 known compounds were isolated from the twig of Hamamelis japonica Sieb. et Zucc. The chemical constituent study of the twig of H. japonica has performed for the first time in the present investigation. Their structures were determined based on extensive spectroscopic methods including 1 D and 2 D NMR and CD spectra data. All isolated compounds were tested for their antiviral activities against HRV1B-, EV71-, PR8- and CVB3-infected Vero cells. Among the tested compounds, (-)-epigallocatechin 3-O-gallate exhibited the most consistent and effective antiviral activities against EV71 and PR8 infections.

引用

页码：863 / 870

页数：8

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