Targeting and engineering long non-coding RNAs for cancer therapy

被引：88

作者：

Coan, Michela ^{[1
,2
,3
]}

Haefliger, Simon ^{[4
,5
]}

Ounzain, Samir ^{[6
]}

Johnson, Rory ^{[1
,2
,4
,5
,7
]}

机构：

[1] Univ Coll Dublin, Sch Biol & Environm Sci, Dublin, Ireland

[2] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin, Ireland

[3] Univ Coll Dublin, Sch Med, Dublin, Ireland

[4] Univ Bern, Bern Univ Hosp, Dept Med Oncol, Inselspital, Bern, Switzerland

[5] Univ Bern, Dept Biomed Res, Bern, Switzerland

[6] HAYA Therapeut, Lausanne, Vaud, Switzerland

[7] FutureNeuro, SFI Res Ctr Chron & Rare Neurol Dis, Dublin, Ireland

来源：

NATURE REVIEWS GENETICS | 2024年 / 25卷 / 08期

基金：

爱尔兰科学基金会;

关键词：

ANTISENSE OLIGONUCLEOTIDES; GENE-EXPRESSION; UP-REGULATION; CELL-PROLIFERATION; HEPATOCELLULAR-CARCINOMA; EVOLUTIONARY DYNAMICS; LIPID NANOPARTICLES; CERVICAL-CANCER; POOR-PROGNOSIS; BINDING-SITES;

D O I：

10.1038/s41576-024-00693-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most promising targets are long non-coding RNAs (lncRNAs), which regulate oncogenic molecular networks in a cell type-restricted manner. lncRNAs are distinct from protein-coding genes in important ways that increase their therapeutic potential yet also present hurdles to conventional clinical development. Advances in genome editing, oligonucleotide chemistry, multi-omics and RNA engineering are paving the way for efficient and cost-effective lncRNA-focused drug discovery pipelines. In this Review, we present the emerging field of lncRNA therapeutics for oncology, with emphasis on the unique strengths and challenges of lncRNAs within the broader RNATx framework. We outline the necessary steps for lncRNA therapeutics to deliver effective, durable, tolerable and personalized treatments for cancer. Therapeutics that target long non-coding RNAs (lncRNAs) are promising treatments for cancer. In this Review, the authors discuss how technological advances have helped improve drug discovery pipelines for lncRNAs and overview their strengths and challenges as oncological therapeutics.

引用

页码：578 / 595

页数：18

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