The person-to-person transmission landscape of the gut and oral microbiomes

被引：170

作者：

Valles-Colomer, Mireia ^{[1
]}

Blanco-Miguez, Aitor ^{[1
]}

Manghi, Paolo ^{[1
]}

Asnicar, Francesco ^{[1
]}

Dubois, Leonard ^{[1
]}

Golzato, Davide ^{[1
]}

Pinto, Federica ^{[1
]}

Cumbo, Fabio ^{[1
]}

Huang, Kun D. ^{[1
]}

Manara, Serena ^{[1
]}

Masetti, Giulia ^{[1
]}

Pinto, Federica ^{[1
]}

Piperni, Elisa ^{[2
]}

Puncochar, Michal ^{[1
]}

Ricci, Liviana ^{[1
]}

Zolfo, Moreno ^{[1
]}

Farrant, Olivia ^{[3
]}

Goncalves, Adriana ^{[3
]}

Selma-Royo, Marta ^{[1
,4
]}

Binetti, Ana G. ^{[5
]}

Becerra, Jimmy E. ^{[6
]}

Han, Bei ^{[7
]}

Lusingu, John ^{[8
,9
]}

Amuasi, John ^{[9
]}

Amoroso, Loredana ^{[10
]}

Visconti, Alessia ^{[11
]}

Steves, Claire M. ^{[11
]}

Falchi, Mario ^{[11
]}

Filosi, Michele ^{[1
]}

Tett, Adrian ^{[1
,12
]}

Last, Anna ^{[3
]}

Xu, Qian ^{[13
,14
]}

Qin, Nan ^{[13
,14
]}

Qin, Huanlong ^{[13
]}

May, Juergen ^{[15
]}

Eibach, Daniel ^{[15
]}

Corrias, Maria Valeria ^{[16
]}

Ponzoni, Mirco ^{[16
]}

Pasolli, Edoardo ^{[17
]}

Spector, Tim D. ^{[11
]}

Domenici, Enrico ^{[1
,18
]}

Collado, Maria Carmen ^{[4
]}

Segata, Nicola ^{[1
,2
]}

机构：

[1] Univ Trento, Dept CIBIO, Trento, Italy

[2] IEO European Inst Oncol IRCCS, Dept Expt Oncol, Milan, Italy

[3] Fac Infect & Trop Dis, London Sch Hyg & Trop Med, Clin Res Dept, London, England

[4] Inst Agrochem, Food Technol Natl Res Council IATA CSIC, Paterna, Valencia, Spain

[5] Univ Nacl Litoral, Fac Ingn Quim, Inst Lactol Ind CONICET UNL, Santa Fe, Argentina

[6] Univ Metropolitana, Grp Invest Alimentac & Comportamiento Humano, Barranquilla, Colombia

[7] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Xian, Peoples R China

[8] Natl Inst Med Res, Tanga Med Res Ctr, Tanga, Tanzania

[9] Kwame Nkrumah Univ Sci & Technol, Kumasi Ctr Collaborat Res Trop Med, Kumasi, Ghana

[10] IRCCS Ist Giannina Gaslini, Oncol Unit, Genoa, Italy

[11] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

[12] Univ Vienna, Ctr Microbiol & Environm Syst Sci, Vienna, Austria

[13] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Shanghai, Peoples R China

[14] Realbio Genom Inst, Shanghai, Peoples R China

[15] Bernhard Nocht Inst Trop Med, Hamburg, Germany

[16] IRCCS Ist Giannina Gaslini, Lab Expt Therapies Oncol, Genoa, Italy

[17] Univ Naples Federico II, Dept Agr Sci, Portici, Italy

[18] Microsoft Res Fdn, Ctr Computat & Syst Biol COSBI, Rovereto, Italy

来源：

NATURE | 2023年 / 614卷 / 7946期

基金：

欧洲研究理事会; 美国国家卫生研究院; 欧盟地平线“2020”;

关键词：

BACTERIAL TRANSMISSION; FECAL MICROBIOME; LEVEL ANALYSIS; BODY SITES; REVEALS; TRANSPLANT; DYNAMICS; GENOMES; METAGENOMICS; PERSISTENCE;

D O I：

10.1038/s41586-022-05620-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human microbiome is an integral component of the human body and a co-determinant of several health conditions(1,2). However, the extent to which interpersonal relations shape the individual genetic makeup of the microbiome and its transmission within and across populations remains largely unknown(3,4). Here, capitalizing on more than 9,700 human metagenomes and computational strain-level profiling, we detected extensive bacterial strain sharing across individuals (more than 10 million instances) with distinct mother-to-infant, intra-household and intra-population transmission patterns. Mother-to-infant gut microbiome transmission was considerable and stable during infancy (around 50% of the same strains among shared species (strain-sharing rate)) and remained detectable at older ages. By contrast, the transmission of the oral microbiome occurred largely horizontally and was enhanced by the duration of cohabitation. There was substantial strain sharing among cohabiting individuals, with 12% and 32% median strain-sharing rates for the gut and oral microbiomes, and time since cohabitation affected strain sharing more than age or genetics did. Bacterial strain sharing additionally recapitulated host population structures better than species-level profiles did. Finally, distinct taxa appeared as efficient spreaders across transmission modes and were associated with different predicted bacterial phenotypes linked with out-of-host survival capabilities. The extent of microorganism transmission that we describe underscores its relevance in human microbiome studies(5), especially those on non-infectious, microbiome-associated diseases.

引用

页码：125 / +

页数：27