Novel amino-Li resin for water-based solid-phase peptide synthesis

被引：1

作者：

Uth, Christina ^{[1
]}

Englert, Simon ^{[1
]}

Avrutina, Olga ^{[2
]}

Kolmar, Harald ^{[2
]}

Knauer, Sascha ^{[1
,3
]}

机构：

[1] Sulfotools GmbH, Russelsheim, Germany

[2] Tech Univ Darmstadt, Clemens Schopf Inst Organ Chem & Biochem, Darmstadt, Germany

[3] Sulfotools GmbH, Bahnhofspl 1 Bldg C14, D-65428 Russelsheim, Germany

来源：

JOURNAL OF PEPTIDE SCIENCE | 2023年 / 29卷 / 12期

关键词：

ASPPS; Smoc strategy; solid support; sustainable peptide synthesis; water-based peptide synthesis; SUPPORTS;

D O I：

10.1002/psc.3527

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the first application of a novel amino-Li resin to water-based solid-phase peptide synthesis (SPPS) applying the Smoc-protecting group approach. We demonstrated that it is a suitable support for the sustainable water-based alternative to a classical SPPS approach. The resin possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable to the synthesis of difficult sequences and aggregation-prone peptides.

引用

页数：7

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