Synthesis of Bioactive Macrocycles Involving Ring-Closing Metathesis Strategy

被引：3

作者：

Jahan, Nasrin ^{[1
]}

Ansary, Inul ^{[1
]}

机构：

[1] Univ Burdwan, Dept Chem, Burdwan 713104, India

来源：

SYNOPEN | 2023年 / 07卷 / 02期

关键词：

macrocycles; ring-closing metathesis; antiviral; antifungal; anticancer; antibiotic; HCV PROTEASE INHIBITOR; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; OLEFIN METATHESIS; POTENT; ANALOGS; PEPTIDOMIMETICS; REARRANGEMENT; HETEROCYCLES; CONVERGENT;

D O I：

10.1055/s-0042-1751453

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review reports the synthesis of various bioactive macrocycles, involving ring-closing metathesis as a key step, developed since ca. 2000. These macrocycles exhibited biological activities such as antiviral, antifungal, antibacterial, and anticancer activities, and more. Thus, their syntheses and utilization are essential for both synthetic organic and medicinal chemists.

引用

页码：209 / 242

页数：34

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