Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique

被引:5
作者
Filimonova, Elena [1 ,2 ]
Amelina, Evgenia [3 ]
Sazonova, Aleksandra [1 ,4 ]
Zaitsev, Boris [1 ,4 ]
Rzaev, Jamil [1 ,2 ,4 ]
机构
[1] Fed Ctr Neurosurg, Novosibirsk, Russia
[2] Novosibirsk State Med Univ, Dept Neurosurg, Novosibirsk, Russia
[3] Novosibirsk State Univ, Stream Data Analyt & Machine Learning Lab, Novosibirsk, Russia
[4] Novosibirsk State Univ, Dept Neurosci, Inst Med & Psychol, Novosibirsk, Russia
关键词
myelination; magnetic resonance imaging; T1w/T2w mapping; infants; children; BRAIN; CORTEX; RATIO;
D O I
10.3389/fnins.2023.1102691
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children. Methods: Ninety-four patients (0-23 months of age) without structural abnormalities on brain MRI were evaluated by using the T1w/T2w mapping method. The T1w/T2w signal intensity ratio, which reflects white matter integrity and the degree of myelination, was calculated in various brain regions. We performed a Pearson correlation analysis, a LOESS regression analysis, and a 2(nd) order polynomial regression analysis to describe the relationships between the regional metrics and the age of the patients (in months). Results: T1w/T2w ratio values rapidly increased in the first 6-9 months of life and then slowed thereafter. The T1w/T2w mapping technique emphasized the contrast between myelinated and less myelinated structures in all age groups, which resulted in better visualization. There were strong positive correlations between the T1w/T2w ratio values from the majority of white matter ROIs and the subjects' age (R = 0.7-0.9, p < 0.001). Within all of the analyzed regions, there were non-linear relationships between age and T1/T2 ratio values that varied by anatomical and functional location. Regions such as the splenium and the genu of the corpus callosum showed the highest R-2 values, thus indicating less scattering of data and a better fit to the model. Conclusion: The T1w/T2w mapping technique may enhance our diagnostic ability to assess myelination patterns in the brains of infants and young children.
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页数:9
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