Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies

被引：12

作者：

Schillemans, Tessa ^{[1
]}

Iszatt, Nina ^{[2
]}

Remy, Sylvie ^{[3
]}

Schoeters, Greet ^{[3
,4
]}

Fernandez, Mariana F. ^{[5
,6
,7
]}

D'Cruz, Shereen Cynthia ^{[8
]}

Desalegn, Anteneh ^{[9
]}

Haug, Line S. ^{[9
]}

Lignell, Sanna ^{[10
]}

Lindroos, Anna Karin ^{[10
]}

Fabelova, Lucia ^{[11
]}

Murinova, Lubica Palkovicova ^{[11
]}

Kosjek, Tina ^{[12
]}

Tkalec, Ziga ^{[12
]}

Gabriel, Catherine ^{[13
,14
]}

Sarigiannis, Denis ^{[13
,14
,15
]}

Pedraza-Diaz, Susana ^{[16
]}

Esteban-Lopez, Marta ^{[16
]}

Castano, Argelia ^{[16
]}

Rambaud, Loic ^{[17
]}

Riou, Margaux ^{[17
]}

Pauwels, Sara ^{[18
]}

Vanlarebeke, Nik ^{[19
]}

Kolossa-Gehring, Marike ^{[20
]}

Vogel, Nina ^{[20
]}

Uhl, Maria ^{[21
]}

Govarts, Eva ^{[3
]}

Akesson, Agneta ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden

[2] Norwegian Inst Publ Hlth, Div Climate & Environm Hlth, Oslo, Norway

[3] Flemish Inst Technol Res VITO, VITO Hlth, Mol, Belgium

[4] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium

[5] Univ Granada, Ctr Biomed Res CIBM, Granada, Spain

[6] Univ Granada, Sch Med, Granada, Spain

[7] Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain

[8] Univ Rennes, EHESP, INSERM, Irset Inst Rech Sante Environm & Travail, Rennes, France

[9] Norwegian Inst Publ Hlth, Div Food Safety, Oslo, Norway

[10] Swedish Food Agcy, Uppsala, Sweden

[11] Slovak Med Univ, Fac Publ Hlth, Dept Environm Med, Bratislava, Slovakia

[12] Jozef Stefan Inst, Dept Environm Sci, Ljubljana, Slovenia

[13] Aristotle Univ Thessaloniki, Dept Chem Engn, Environm Engn Lab, Thessaloniki 54124, Greece

[14] HERACLES Res Ctr Exposome & Hlth, Ctr Interdisciplinary Res & Innovat, Balkan Ctr, Bldg B,10th Km Thessaloniki Thermi Rd, Thessaloniki 57001, Greece

[15] Inst Adv Study, Environm Hlth Engn, Palazzo Broletto Piazza Vittoria 15, I-27100 Pavia, Italy

[16] Inst Salud Carlos III, Natl Ctr Environm Hlth, Madrid, Spain

[17] Sante Publ France, Dept Environm & Occupat Hlth, St Maurice, France

[18] KU, Dept Publ Hlth & Primary Care, Leuven, Belgium

[19] Free Univ Brussels, Dept Analyt & Environm Chem, Brussels, Belgium

[20] Umweltbundesamt UBA, German Environm Agcy, Berlin, Germany

[21] Environm Agcy Austria, Vienna, Austria

来源：

ENVIRONMENTAL POLLUTION | 2023年 / 316卷

基金：

瑞典研究理事会;

关键词：

per -and polyfluoroalkyl substances; Body mass index; Teenagers; HBM4EU; PERFLUOROALKYL SUBSTANCES; PERFLUOROOCTANOIC ACID; PRENATAL EXPOSURE; ADIPOSITY; ALPHA; ADOLESCENTS; ACTIVATION; RECEPTORS; CHEMICALS; OBESITY;

D O I：

10.1016/j.envpol.2022.120566

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Per-and polyfluoroalkyl substances (PFAS) are widespread pollutants that may impact youth adiposity patterns. We investigated cross-sectional associations between PFAS and body mass index (BMI) in teenagers/adolescents across nine European countries within the Human Biomonitoring for Europe (HBM4EU) initiative. We used data from 1957 teenagers (12-18 yrs) that were part of the HBM4EU aligned studies, consisting of nine HBM studies (NEBII, Norway; Riksmaten Adolescents 2016-17, Sweden; PCB cohort (follow-up), Slovakia; SLO CRP, Slovenia; CROME, Greece; BEA, Spain; ESTEBAN, France; FLEHS IV, Belgium; GerES V-sub, Germany). Twelve PFAS were measured in blood, whilst weight and height were measured by field nurse/physician or self-reported in ques-tionnaires. We assessed associations between PFAS and age-and sex-adjusted BMI z-scores using linear and logistic regression adjusted for potential confounders. Random-effects meta-analysis and mixed effects models were used to pool studies. We assessed mixture effects using molar sums of exposure biomarkers with toxicological/structural similarities and quantile g-computation. In all studies, the highest concentrations of PFAS were PFOS (medians ranging from 1.34 to 2.79 mu g/L). There was a tendency for negative associations with BMI z-scores for all PFAS (except for PFHxS and PFHpS), which was borderline significant for the molar sum of [PFOA and PFNA] and significant for single PFOA [beta-coefficient (95% CI) per interquartile range fold change =-0.06 (-0.17, 0.00) and-0.08 (-0.15,-0.01), respectively]. Mixture assessment indicated similar negative associations of the total mixture of [PFOA, PFNA, PFHxS and PFOS] with BMI z-score, but not all compounds showed associations in the same direction: whilst [PFOA, PFNA and PFOS] were negatively associated, [PFHxS] associated positively with BMI z-score. Our results indicated a tendency for associations of relatively low PFAS concentrations with lower BMI in European teenagers. More prospective research is needed to investigate this potential relationship and its implications for health later in life.

引用

页数：11

共 61 条

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