Controlled release of theophylline from ethyl cellulose coated PVA/NaCMC-theophylline microspheres

被引：3

作者：

Kirkayak, Nurcan Cicek ^{[1
]}

Solak, Ebru Kondolot ^{[1
,2
]}

机构：

[1] Gazi Univ, Dept Adv Technol, Ankara, Turkey

[2] Gazi Univ, Tech Sci Vocat Sch, Dept Chem & Chem Proc Technol, Ankara, Turkey

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2023年 / 72卷 / 11期

关键词：

Asthma; controlled release; microsphere; polyvinyl alcohol; sodium carboxymethyl cellulose; theophylline; POLYMER NETWORK MICROSPHERES; DRUG-RELEASE; CARBOXYMETHYL CELLULOSE; SODIUM ALGINATE; CHITOSAN; HYDROGELS;

D O I：

10.1080/00914037.2022.2063288

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Theophylline (TF) was preferably used for the treatment of asthma and chronic obstructive pulmonary diseases. However, it has a limited therapeutic range. So the controlled release of theophylline is required. In this study, TF was encapsulated with poly (vinyl alcohol) (PVA) and sodium carboxy methyl cellulose (NaCMC) polymers by using ionic gelation and liquid ripening method and iron III chloride (FeCl3) was used as crosslinking agent. Prepared microspheres were characterized and also defined by equilibrium swelling values and release profiles. Microspheres, in which the most suitable release conditions were determined, coated with EC and drug release studies were carried out.

引用

页码：825 / 833

页数：9

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