Cynara cardunculus L. var. scolymus L. Landrace "Carciofo Ortano" as a Source of Bioactive Compounds

被引：6

作者：

Masci, Valentina Laghezza ^{[1
]}

Alicandri, Enrica ^{[1
]}

Antonelli, Chiara ^{[1
]}

Paolacci, Anna Rita ^{[1
]}

Marabottini, Rosita ^{[1
]}

Tomassi, William ^{[1
]}

Mugnozza, Giuseppe Scarascia ^{[1
]}

Tiezzi, Antonio ^{[1
]}

Garzoli, Stefania ^{[2
]}

Vinciguerra, Vittorio ^{[1
]}

Vettraino, Anna Maria ^{[1
]}

Ovidi, Elisa ^{[1
]}

Ciaffi, Mario ^{[1
]}

机构：

[1] Tuscia Univ, Dept Innovat Biol Agrofood & Forestal Syst, I-01100 Viterbo, Italy

[2] Sapienza Univ, Dept Drug Chem & Technol, I-00185 Rome, Italy

来源：

PLANTS-BASEL | 2024年 / 13卷 / 06期

关键词：

Cynara cardunculus L. var. scolymus; Carciofo Ortano" landrace; artichoke waste; artichoke leaf extracts; phenolic composition; volatile organic compounds (VOCs); secondary metabolites; cytotoxicity; Alternaria alternata; PHENOLIC-COMPOUNDS; GLOBE ARTICHOKE; ANTIMICROBIAL ACTIVITY; CAFFEOYLQUINIC ACIDS; MEDICINAL-PLANTS; FUNCTIONAL FOOD; LEAF; LEAVES; IDENTIFICATION; ANTIOXIDANT;

D O I：

10.3390/plants13060761

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The preservation of agricultural biodiversity and socioeconomic development are relevant both to enhance domestic production and to support innovation. In the search for new biomolecules, we have focused on the "Carciofo Ortano" landrace, growth in the northern part of the Lazio region. Artichoke cultivation generates substantial by-products, including leaves, stems, and roots, which could serve as valuable sources of biomolecules and prebiotic dietary fiber. To valorize the leaf waste of the "Carciofo Ortano" landrace, a multidisciplinary approach was applied. Chemical analysis using HPLC-DAD identified mono-O- and di-O-caffeoylquinic acids and the sesquiterpene cynaropicrin in all artichoke leaf extracts. SPME-GC/MS analyses detected aliphatic alcohols in the fresh leaf samples. Antiproliferative and cytotoxic studies on cancer (SH-SY5Y, MCF-7, MDA) and normal (MCF-10A) human cell lines revealed that leaf extracts induced a selective dose and time-dependent biological effect. While showing slight activity against environmental bacterial strains, artichoke leaf extracts exhibited significant antifungal activity against the phytopathogenic fungus Alternaria alternata. Overall, the results highlight the potential of "Carciofo Ortano" cultivation by-products as a rich source of biomolecules with versatile applications in humans, animals, and the environment.

引用

页数：19

共 80 条

[1] Morphological, Molecular, and Nutritional Characterisation of the Globe Artichoke Landrace "Carciofo Ortano" [J].