Amaryllidaceae alkaloids from the bulbs of Crinum latifolium L. and their cholinesterase inhibitory activities

被引：5

作者：

Chaichompoo, Waraluck ^{[1
,2
]}

Rojsitthisak, Pornchai ^{[1
,2
]}

Pabuprapap, Wachirachai ^{[3
,4
]}

Siriwattanasathien, Yuttana ^{[3
,4
]}

Yotmanee, Pathumwadee ^{[3
,4
]}

Suksamrarn, Apichart ^{[3
,4
]}

机构：

[1] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Food & Pharmaceut Chem, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Ctr Excellence Nat Prod Aging & Chron Dis, Bangkok 10330, Thailand

[3] Ramkhamhang Univ, Dept Chem, Fac Sci, Bangkok 10240, Thailand

[4] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10240, Thailand

来源：

PHYTOCHEMISTRY | 2024年 / 217卷

关键词：

Crinum latifolium L; Amaryllidaceae; Alkaloids; Acetylcholinesterase; Butyrylcholinesterase; SOUTH-AFRICAN AMARYLLIDACEAE; CHEMICAL-CONSTITUENTS; LYCORINE; EXTRACTS; CONFIGURATION; HIPPEASTRUM; AUGUSTAMINE; METABOLISM; ANAMNESIS; HERB;

D O I：

10.1016/j.phytochem.2023.113929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eleven previously undescribed Amaryllidaceae alkaloids, crinalatifolines A-K (1-11), and two first naturally occurring alkaloids, dihydroambelline (12) and N-demethyldihydrogalanthamine (13), were isolated from the bulbs of Crinum latifolium L. Additionally, thirty-seven known alkaloids and one alkaloid artifact were also isolated from this plant species. Their structures and absolute configurations were elucidated using extensive spectroscopic techniques, including IR, NMR, MS, and ECD. Evaluations of the cholinesterase inhibitory activities of most of these compounds were conducted. Among the tested compounds, ungeremine exhibited the highest potency against acetylcholinesterase and butyrylcholinesterase, with the IC50 values of 0.10 and 1.21 mu M, respectively. These values were 9.4- and 2.4-fold more potent than the reference drug galanthamine.

引用

页数：14

共 105 条

[1] 2-ORTHO-ACETYL CHLIDANTHINE - AN ALKALOID FROM HAEMANTHUS-MULTIFLORUS [J].