Safety and efficacy of SARS-CoV-2 vaccination in patients with immune thrombocytopenia: A two-centre review

被引：2

作者：

Stefani, Sara ^{[1
,2
]}

Buti, Noora ^{[1
]}

Hart, Alice C. J. ^{[1
,2
]}

Paul, Deena ^{[1
]}

Rizvi, Naghma ^{[1
]}

Ragoonanan, Vashti ^{[1
]}

Vladescu, Camelia ^{[1
]}

Szydlo, Richard ^{[2
]}

Ademokun, Christine ^{[1
]}

Jansen, A. J. Gerard ^{[3
]}

Cooper, Nichola ^{[1
,2
]}

机构：

[1] Imperial Coll Healthcare NHS Trust, London, England

[2] Imperial Coll London, Ctr Haematol, Dept Immunol & Inflammat, London, England

[3] Univ Med Ctr Rotterdam, Erasmus MC, Dept Haematol, Rotterdam, Netherlands

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 01期

关键词：

antibodies; COVID-19; ITP; vaccines; COVID-19; VACCINATION;

D O I：

10.1111/bjh.19212

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple studies have reported immune thrombocytopenia (ITP) relapse following SARS-CoV-2 vaccination, however baseline ITP relapse rate and antibody response to vaccination are not known. Patients with ITP who received at least one of the first three SARS-CoV-2 vaccination doses were included in the study. One hundred and twenty-four patients met the inclusion criteria. Relapse rate was 4.2% following a first vaccine dose, 9.1% after a second and 2.9% after a third; baseline relapse rate was 7.6%. Ninety-four per cent of patients who received three vaccine doses developed a clinical antibody response. SARS-CoV-2 vaccination appears to be safe and effective in patients with ITP.

引用

页码：324 / 328

页数：5

共 8 条

[1] Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study
Bernal, Jamie Lopez
Andrews, Nick
Gower, Charlotte
Robertson, Chris
Stowe, Julia
Tessier, Elise
Simmons, Ruth
Cottrell, Simon
Roberts, Richard
O'Doherty, Mark
Brown, Kevin
Cameron, Claire
Stockton, Diane
McMenamin, Jim
Ramsay, Mary
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2021, 373
[2] Safety of anti-SARS-CoV-2 vaccination for patients with immune thrombocytopenia
Crickx, Etienne
Moulis, Guillaume
Ebbo, Mikael
Terriou, Louis
Briantais, Antoine
Languille, Laetitia
Limal, Nicolas
Guillet, Stephanie
Michel, Marc
Mahevas, Matthieu
Godeau, Bertrand
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2021, 195 (05) : 703 - 705
[3] Exacerbation of immune thrombocytopenia following COVID-19 vaccination
Kuter, David J.
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2021, 195 (03) : 365 - 370
[4] SARS-CoV-2 vaccination and ITP in patients with de novo or preexisting ITP
Lee, Eun-Ju
Beltrami-Moreira, Marina
Al-Samkari, Hanny
Cuker, Adam
DiRaimo, Jennifer
Gernsheimer, Terry
Kruse, Alexandra
Kessler, Craig
Kruse, Caroline
Leavitt, Andrew D.
Lee, Alfred, I
Liebman, Howard A.
Newland, Adrian C.
Ray, Ashley E.
Tarantino, Michael D.
Thachil, Jecko
Kuter, David J.
Cines, Douglas B.
Bussel, James B.
[J]. BLOOD, 2022, 139 (10) : 1564 - 1574
[5] Spike-antibody waning after second dose of BNT162b2 or ChAdOx1
Shrotri, Madhumita
Navaratnam, Annalan M. D.
Nguyen, Vincent
Byrne, Thomas
Geismar, Cyril
Fragaszy, Ellen
Beale, Sarah
Fong, Wing Lam Erica
Patel, Parth
Kovar, Jana
Hayward, Andrew C.
Aldridge, Robert W.
[J]. LANCET, 2021, 398 (10298) : 385 - 387
[6] Humoral response to coronavirus disease-19 vaccines is dependent on dosage and timing of rituximab in patients with rheumatoid arthritis
van der Togt, Celeste J. T.
Ten Cate, David F.
den Broeder, Nathan
Rahamat-Langendoen, Janette
van den Bemt, Bart J. F.
den Broeder, Alfons A.
[J]. RHEUMATOLOGY, 2022, 61 (SI2) : SI175 - SI179
[7] COVID-19 vaccination in patients with immune thrombocytopenia
Visser, Chantal
Swinkels, Maurice
van Werkhoven, Erik D.
Croles, F. Nanne
Noordzij-Nooteboom, Heike S.
Eefting, Matthijs
Last-Koopmans, Suzanne M.
Idink, Cecile
Westerweel, Peter E.
Santbergen, Bart
Jobse, Pieter A.
Baboe, Fazil
Te Boekhorst, Peter A. W.
Leebeek, Frank W. G.
Levin, Mark-David
Kruip, Marieke J. H. A.
Jansen, A. J. Gerard
[J]. BLOOD ADVANCES, 2022, 6 (06) : 1637 - 1644
[8] Global impact of the first year of COVID-19 vaccination: a mathematical modelling study
Watson, Oliver J.
Barnsley, Gregory
Toor, Jaspreet
Hogan, Alexandra B.
Winskill, Peter
Ghani, Azra C.
[J]. LANCET INFECTIOUS DISEASES, 2022, 22 (09) : 1293 - 1302

← 1 →