Behavioural genetics methods

被引:22
|
作者
Willoughby, Emily A. A. [1 ]
Polderman, Tinca J. C. [2 ,3 ]
Boutwell, Brian B. B. [4 ,5 ]
机构
[1] Univ Minnesota Twin Cities, Dept Psychol, Minneapolis, MN USA
[2] Vrije Univ, Dept Clin Dev Psychol, Amsterdam, Netherlands
[3] Amsterdam UMC, Dept Child & Adolescent Psychiat & Social Care, Amsterdam, Netherlands
[4] Univ Mississippi, Sch Appl Sci, University, MS 38677 USA
[5] Univ Mississippi Med Ctr, John D Bower Sch Populat Hlth, Jackson, MS 39216 USA
来源
NATURE REVIEWS METHODS PRIMERS | 2023年 / 3卷 / 01期
关键词
ENVIRONMENTAL-INFLUENCES; FAMILY DATA; TWIN; HERITABILITY; PERSONALITY; MINNESOTA; ADOPTION; METAANALYSIS; ACCURACY; UTILITY;
D O I
10.1038/s43586-022-00191-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Behavioural genetics examines the underlying factors associated with individual differences in behaviours and capacities. In this Primer, Willoughby et al. discuss the methods used in behavioural genetics analysis, in particular twin studies, genome-wide association studies and statistical modelling. The question of why people show individual differences in their behaviours and capacities has intrigued researchers for centuries. Behaviour genetics offers us various methods to address this question. The answers are interesting for a range of research fields, varying from medicine to psychology, economics and neuroscience. Starting with twin and family studies in the late 1970s, the field of behaviour genetics has rapidly developed by applying molecular genetic techniques next to, and sometimes combined with, family data. The overarching conclusion at this point in time is that all measured human traits are to some extent heritable, and that many genetic variants, with each exerting a small effect, explain this heritability. Against this backdrop, we offer readers who might be less familiar with behaviour genetics a brief Primer on the topic. Sitting atop our list of goals is to be a resource for scholars interested in applying the widely useful techniques of the field to their particular specialty, regardless of what that might be.
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收藏
页数:16
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