Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies

被引：10

作者：

Wang, Liping ^{[1
]}

Chen, Zhe ^{[2
]}

Liu, Guohong ^{[3
]}

Pan, Yunbao ^{[1
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp Wuhan Univ, Dept Lab Med, Wuhan 430071, Hubei, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp Wuhan Univ, Dept Otolaryngol Head & Neck Surg, Wuhan 430071, Hubei, Peoples R China

[3] Wuhan Univ, Zhongnan Hosp Wuhan Univ, Dept Radiol, Wuhan 430071, Hubei, Peoples R China

来源：

GENES & DISEASES | 2023年 / 10卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Cellular communication; Immune checkpoints; Immunotherapy; Natural killer cells; Tumor microenvironment; INFILTRATING NK CELLS; DENDRITIC CELLS; T-CELLS; HEPATOCELLULAR-CARCINOMA; POLIOVIRUS RECEPTOR; SUPPRESSOR-CELLS; GAMMA PRODUCTION; IFN-GAMMA; EXPRESSION; CANCER;

D O I：

10.1016/j.gendis.2022.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells, the dynamic phenotypic changes of NK cells in the TME, and the communication between NK cells and other immune and nonimmune cells. (c) 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).

引用

页码：990 / 1004

页数：15

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