Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease

被引：6
作者：
Wu, Meng [1 ]
Pei, Zhiyin [1 ]
Long, Guangfeng [1 ]
Chen, Hongbing [1 ]
Jia, Zhanjun [2 ,3 ]
Xia, Weiwei [1 ,2 ,3 ]
机构：
[1] Nanjing Med Univ, Dept Clin Lab, Childrens Hosp, Nanjing, Peoples R China
[2] Nanjing Med Univ, Dept Nephrol, Childrens Hosp, Nanjing, Peoples R China
[3] Nanjing Med Univ, Jiangsu Key Lab Pediat, Nanjing, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
MAVS; renal disease; innate immune; NLRP3; inflammation; NF-KAPPA-B; NLRP3 INFLAMMASOME ACTIVATION; INDUCIBLE GENE-I; RIG-I; ADAPTER PROTEIN; INNATE IMMUNITY; KIDNEY-DISEASE; ENDOPLASMIC-RETICULUM; MAVS; INTERFERON;
D O I：
10.3389/fimmu.2023.1266461
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mitochondrial antiviral signaling protein (MAVS) is a key innate immune adaptor on the outer mitochondrial membrane that acts as a switch in the immune signal transduction response to viral infections. Some studies have reported that MAVS mediates NF-kappa B and type I interferon signaling during viral infection and is also required for optimal NLRP3 inflammasome activity. Recent studies have reported that MAVS is involved in various cancers, systemic lupus erythematosus, kidney diseases, and cardiovascular diseases. Herein, we summarize the structure, activation, pathophysiological roles, and MAVS-based therapies for renal diseases. This review provides novel insights into MAVS's role and therapeutic potential in the pathogenesis of renal diseases.
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页数：10
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共 110 条
  • [21] Enterovirus 2APro Targets MDA5 and MAVS in Infected Cells
    Feng, Qian
    Langereis, Martijn A.
    Lork, Marie
    Mai Nguyen
    Hato, Stanleyson V.
    Lanke, Kjerstin
    Emdad, Luni
    Bhoopathi, Praveen
    Fisher, Paul B.
    Lloyd, Richard E.
    van Kuppeveld, Frank J. M.
    [J]. JOURNAL OF VIROLOGY, 2014, 88 (06) : 3369 - 3378
  • [22] RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury
    Fischer, Julius C.
    Bscheider, Michael
    Eisenkolb, Gabriel
    Lin, Chia-Ching
    Wintges, Alexander
    Otten, Vera
    Lindemans, Caroline A.
    Heidegger, Simon
    Rudelius, Martina
    Monette, Sebastien
    Rodriguez, Kori A. Porosnicu
    Calafiore, Marco
    Liebermann, Sophie
    Liu, Chen
    Lienenklaus, Stefan
    Weiss, Siegfried
    Kalinke, Ulrich
    Ruland, Juergen
    Peschel, Christian
    Shono, Yusuke
    Docampo, Melissa
    Velardi, Enrico
    Jenq, Robert R.
    Hanash, Alan M.
    Dudakov, Jarrod A.
    Haas, Tobias
    van den Brink, Marcel R. M.
    Poeck, Hendrik
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (386)
  • [23] IKKε and TBK1 are essential components of the IRF3 signaling pathway
    Fitzgerald, KA
    McWhirter, SM
    Faia, KL
    Rowe, DC
    Latz, E
    Golenbock, DT
    Coyle, AJ
    Liao, SM
    Maniatis, T
    [J]. NATURE IMMUNOLOGY, 2003, 4 (05) : 491 - 496
  • [24] Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
    Guo, Beichu
    Cheng, Genhong
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (16) : 11817 - 11826
  • [25] RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation
    He, Xiang
    Zhu, Yongjie
    Zhang, Yanhong
    Geng, Yunqi
    Gong, Jing
    Geng, Jin
    Zhang, Pingping
    Zhang, Xiaotong
    Liu, Ning
    Peng, Yumeng
    Wang, Chenbin
    Wang, Yujie
    Liu, Xin
    Wan, Luming
    Gong, Feng
    Wei, Congwen
    Zhong, Hui
    [J]. EMBO JOURNAL, 2019, 38 (14)
  • [26] MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
    Hou, Fajian
    Sun, Lijun
    Zheng, Hui
    Skaug, Brian
    Jiang, Qiu-Xing
    Chen, Zhijian J.
    [J]. CELL, 2011, 146 (03) : 448 - 461
  • [27] MiR-3470b promotes bovine ephemeral fever virus replication via directly targeting mitochondrial antiviral signaling protein (MAVS) in baby hamster Syrian kidney cells
    Hou, Peili
    Wang, Hongmei
    Zhao, Guimin
    Hu, Guixue
    Xia, Xianzhu
    He, Hongbin
    [J]. BMC MICROBIOLOGY, 2018, 18
  • [28] MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD
    Hsu, Alan C-Y.
    Dua, Kamal
    Starkey, Malcolm R.
    Haw, Tatt-Jhong
    Nair, Prema M.
    Nichol, Kristy
    Zammit, Nathan
    Grey, Shane T.
    Baines, Katherine J.
    Foster, Paul S.
    Hansbro, Philip M.
    Wark, Peter A.
    [J]. JCI INSIGHT, 2017, 2 (07)
  • [29] RIG-1 and MDA-5 signaling pathways contribute to IFN-β production and viral replication in porcine circovirus virus type 2-infected PK-15 cells in vitro
    Huang, Bei
    Li, Jiansheng
    Zhang, Xinchen
    Zhao, Qiling
    Lu, Mingqing
    Lv, Yingjun
    [J]. VETERINARY MICROBIOLOGY, 2017, 211 : 36 - 42
  • [30] Negative Regulation of MAVS-Mediated Innate Immune Response by PSMA7
    Jia, Yongxia
    Song, Ting
    Wei, Congwen
    Ni, Caifei
    Zheng, Zirui
    Xu, Quanbin
    Ma, Hongfang
    Li, Li
    Zhang, Yanhong
    He, Xiang
    Xu, Yang
    Shi, Wei
    Zhong, Hui
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (07) : 4241 - 4248
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