Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease

被引：6
作者：
Wu, Meng [1 ]
Pei, Zhiyin [1 ]
Long, Guangfeng [1 ]
Chen, Hongbing [1 ]
Jia, Zhanjun [2 ,3 ]
Xia, Weiwei [1 ,2 ,3 ]
机构：
[1] Nanjing Med Univ, Dept Clin Lab, Childrens Hosp, Nanjing, Peoples R China
[2] Nanjing Med Univ, Dept Nephrol, Childrens Hosp, Nanjing, Peoples R China
[3] Nanjing Med Univ, Jiangsu Key Lab Pediat, Nanjing, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
MAVS; renal disease; innate immune; NLRP3; inflammation; NF-KAPPA-B; NLRP3 INFLAMMASOME ACTIVATION; INDUCIBLE GENE-I; RIG-I; ADAPTER PROTEIN; INNATE IMMUNITY; KIDNEY-DISEASE; ENDOPLASMIC-RETICULUM; MAVS; INTERFERON;
D O I：
10.3389/fimmu.2023.1266461
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mitochondrial antiviral signaling protein (MAVS) is a key innate immune adaptor on the outer mitochondrial membrane that acts as a switch in the immune signal transduction response to viral infections. Some studies have reported that MAVS mediates NF-kappa B and type I interferon signaling during viral infection and is also required for optimal NLRP3 inflammasome activity. Recent studies have reported that MAVS is involved in various cancers, systemic lupus erythematosus, kidney diseases, and cardiovascular diseases. Herein, we summarize the structure, activation, pathophysiological roles, and MAVS-based therapies for renal diseases. This review provides novel insights into MAVS's role and therapeutic potential in the pathogenesis of renal diseases.
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页数：10
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共 110 条
  • [1] Regulation of cGAS- and RLR-mediated immunity to nucleic acids
    Ablasser, Andrea
    Hur, Sun
    [J]. NATURE IMMUNOLOGY, 2020, 21 (01) : 17 - 29
  • [2] The functions of animal microRNAs
    Ambros, V
    [J]. NATURE, 2004, 431 (7006) : 350 - 355
  • [3] The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury
    Anders, Hans-Joachim
    Suarez-Alvarez, Beatriz
    Grigorescu, Melissa
    Foresto-Neto, Orestes
    Steiger, Stefanie
    Desai, Jyaysi
    Marschner, Julian A.
    Honarpisheh, Mohsen
    Shi, Chongxu
    Jordan, Jutta
    Mueller, Lisa
    Burzlaff, Nicolai
    Baeuerle, Tobias
    Mulay, Shrikant R.
    [J]. KIDNEY INTERNATIONAL, 2018, 93 (03) : 656 - 669
  • [4] MAVS Dimer Is a Crucial Signaling Component of Innate Immunity and the Target of Hepatitis C Virus NS3/4A Protease
    Baril, Martin
    Racine, Marie-Eve
    Penin, Francois
    Lamarre, Daniel
    [J]. JOURNAL OF VIROLOGY, 2009, 83 (03) : 1299 - 1311
  • [5] Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter
    Belgnaoui, S. Mehdi
    Paz, Suzanne
    Hiscott, John
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (05) : 564 - 572
  • [6] The influenza A virus matrix protein 2 undergoes retrograde transport from the endoplasmic reticulum into the cytoplasm and bypasses cytoplasmic proteasomal degradation
    Bhowmick, Sanchari
    Chakravarty, Chandrani
    Sellathamby, Shanmugaapriya
    Lal, Sunil K.
    [J]. ARCHIVES OF VIROLOGY, 2017, 162 (04) : 919 - 929
  • [7] RIG-I/MDA5/MAVS Are Required To Signal a Protective IFN Response in Rotavirus-Infected Intestinal Epithelium
    Broquet, Alexis H.
    Hirata, Yoshihiro
    McAllister, Christopher S.
    Kagnoff, Martin F.
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 186 (03) : 1618 - 1626
  • [8] Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus
    Buskiewicz, Iwona A.
    Montgomery, Theresa
    Yasewicz, Elizabeth C.
    Huber, Sally A.
    Murphy, Michael P.
    Hartley, Richard C.
    Kelly, Ryan
    Crow, Mary K.
    Perl, Andras
    Budd, Ralph C.
    Koenig, Andreas
    [J]. Science Signaling, 2016, 9 (456)
  • [9] G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses
    Cai, Hong
    Liu, Xin
    Zhang, Feng
    Han, Qiu-Ying
    Liu, Zhao-Shan
    Xue, Wen
    Guo, Zeng-Lin
    Zhao, Jiang-Man
    Sun, Li-Ming
    Wang, Na
    Mao, Jie
    He, Kun
    Xia, Tian
    Chen, Yuan
    Chen, Liang
    Li, Ai-Ling
    Zhou, Tao
    Zhang, Xue-Min
    Li, Wei-Hua
    Li, Tao
    [J]. JOURNAL OF IMMUNOLOGY, 2021, 206 (10) : 2453 - 2467
  • [10] MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors
    Castanier, Celine
    Zemirli, Naima
    Portier, Alain
    Garcin, Dominique
    Bidere, Nicolas
    Vazquez, Aime
    Arnoult, Damien
    [J]. BMC BIOLOGY, 2012, 10
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