Flumatinib plus venetoclax as an effective therapy for Philadelphia chromosome-positive acute myeloid leukemia: A case report

被引:2
作者
Huang, Si-Man [1 ,2 ]
Tao, Tao [3 ,4 ]
Wan, Chao-Ling [1 ,2 ]
Wu, Tian-Mei [1 ,2 ]
Cao, Han-Yu [1 ,2 ]
Qiu, Yan [1 ,2 ]
Shen, Xiang-Dong [1 ,2 ]
Wang, Bin-Ru [1 ,2 ]
Ge, Shuai-Shuai [1 ,2 ]
Li, Yan-Yan [1 ,2 ]
Zhang, Tong-Tong [1 ,2 ]
Wu, Bing [5 ]
Xue, Sheng-Li [1 ,2 ]
机构
[1] Soochow Univ, Jiangsu Inst Hematol, Natl Clin Res Ctr Hematol Dis, Affiliated Hosp 1, 188 Shizi St, Suzhou 215006, Peoples R China
[2] Soochow Univ, Inst Blood & Marrow Transplantat, Collaborat Innovat Ctr Hematol, Suzhou, Peoples R China
[3] Fifth Peoples Hosp Suzhou, Dept Resp & Crit Med, Suzhou, Peoples R China
[4] Soochow Univ, Dept Resp & Crit Med, Affiliated Infect Dis Hosp, Suzhou, Peoples R China
[5] Nanjing Univ Chinese Tradit Med, Suzhou Hosp Chinese Tradit Med, Affiliated Hosp, 889 West Wuzhong Rd, Suzhou 215006, Peoples R China
关键词
flumatinib; Philadelphia chromosome-positive acute myeloid leukemia; regimen; venetoclax; CELL TRANSPLANTATION;
D O I
10.1002/ccr3.6688
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Philadelphia chromosome-positive acute myeloid leukemia (Ph + AML) is a rare type of AML with a low survival rate and poor prognosis. We first report a Ph + AML patient who remained in long-term remission after the combination of flumatinib and venetoclax, which could provide corresponding treatment ideas for clinical practice.
引用
收藏
页数:5
相关论文
共 18 条
[1]   Allogeneic Stem Cell Transplantation for Philadelphia Chromosome-Positive Acute Myeloid Leukemia [J].
Bhatt, Vijaya Raj ;
Akhtari, Mojtaba ;
Bociek, Gregory ;
Sanmann, Jennifer N. ;
Yuan, Ji ;
Dave, Bhavana J. ;
Sanger, Warren G. ;
Kessinger, Anne ;
Armitage, James O. .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2014, 12 (07) :963-968
[2]   Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells [J].
Carter, Bing Z. ;
Mak, Po Yee ;
Mu, Hong ;
Zhou, Hongsheng ;
Mak, Duncan H. ;
Schober, Wendy ;
Leverson, Joel D. ;
Zhang, Bin ;
Bhatia, Ravi ;
Huang, Xuelin ;
Cortes, Jorge ;
Kantarjian, Hagop ;
Konopleva, Marina ;
Andreeff, Michael .
SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (355)
[3]  
Cuneo A, 1996, HAEMATOLOGICA, V81, P423
[4]   Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel [J].
Doehner, Hartmut ;
Estey, Elihu ;
Grimwade, David ;
Amadori, Sergio ;
Appelbaum, Frederick R. ;
Buechner, Thomas ;
Dombret, Herve ;
Ebert, Benjamin L. ;
Fenaux, Pierre ;
Larson, Richard A. ;
Levine, Ross L. ;
Lo-Coco, Francesco ;
Naoe, Tomoki ;
Niederwieser, Dietger ;
Ossenkoppele, Gert J. ;
Sanz, Miguel ;
Sierra, Jorge ;
Tallman, Martin S. ;
Tien, Hwei-Fang ;
Wei, Andrew H. ;
Lowenberg, Bob ;
Bloomfield, Clara D. .
BLOOD, 2017, 129 (04) :424-447
[5]   Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemia [J].
Konoplev, Sergej ;
Yin, C. Cameron ;
Kornblau, Steven M. ;
Kantarjian, Hagop M. ;
Konopleva, Marina ;
Andreeff, Michael ;
Lu, Gary ;
Zuo, Zhuang ;
Luthra, Rajyalakshmi ;
Medeiros, L. Jeffrey ;
Bueso-Ramos, Carlos E. .
LEUKEMIA & LYMPHOMA, 2013, 54 (01) :138-144
[6]   Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia [J].
Leonard, Jessica T. ;
Rowley, Joelle S. J. ;
Eide, Christopher A. ;
Traer, Elie ;
Hayes-Lattin, Brandon ;
Loriaux, Marc ;
Spurgeon, Stephen E. ;
Druker, Brian J. ;
Tyner, Jeffrey W. ;
Chang, Bill H. .
SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (354)
[7]  
Leukemia & Lymphoma Group Chinese Society of Hematology Chinese Medical Association, 2021, Zhonghua Xue Ye Xue Za Zhi, V42, P617, DOI 10.3760/cma.j.issn.0253-2727.2021.08.001
[8]   Venetoclax and BCR-ABL Tyrosine Kinase Inhibitor Combinations: Outcome in Patients with Philadelphia Chromosome-Positive Advanced Myeloid Leukemias [J].
Maiti, Abhishek ;
Franquiz, Miguel J. ;
Ravandi, Farhad ;
Cortes, Jorge E. ;
Jabbour, Elias J. ;
Sasaki, Koji ;
Marx, Kayleigh ;
Daver, Naval G. ;
Kadia, Tapan M. ;
Konopleva, Marina Y. ;
Masarova, Lucia ;
Borthakur, Gautam ;
DiNardo, Courtney D. ;
Naqvi, Kiran ;
Pierce, Sherry ;
Kantarjian, Hagop M. ;
Short, Nicholas J. .
ACTA HAEMATOLOGICA, 2020, 143 (06) :567-573
[9]   The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [J].
Melo, JV .
BLOOD, 1996, 88 (07) :2375-2384
[10]   Impact of an Additional Chromosome on the Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Philadelphia Chromosome-Positive Acute Myeloid Leukemia in Adults [J].
Min, Gi June ;
Kim, Hee-Je ;
Yoon, Jae-Ho ;
Kwak, Dae-Hun ;
Park, Sung-Soo ;
Jeon, Young-Woo ;
Lee, Sung-Eun ;
Cho, Byung-Sik ;
Eom, Ki-Seong ;
Kim, Yoo-Jin ;
Lee, Seok ;
Min, Chang-Ki ;
Cho, Seok-Goo ;
Kim, Dong-Wook ;
Lee, Jong Wook ;
Min, Woo-Sung .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2018, 24 (08) :1621-1628