Application of Metal-Organic Frameworks for Efficient Removal of Doxorubicin Hydrochloride: Removal Process Optimization and Biological Activity

This study looked at the doxorubicin hydrochloride (DOX)anticancerdrug's adsorption characteristics on a silver-based metal-organicframework (Ag-MOF). X-ray diffraction (XRD), scanning electron microscopy(SEM), and X-ray photoelectron spectroscopy (XPS) were used for thecharacterization of Ag-MOF. The pore volume and surface area of Ag-MOFwere determined through Brunauer-Emmett-Teller (BET)testing at 77 K to be 0.509 cm(3)/g and 676.059 m(2)/g, respectively. Adsorption at pH 6 was established to be the bestfor DOX compared to alkaline solution. Ag-MOF has a good capacityfor eliminating DOX (1.85 mmol/g), according to adsorption experiments.Fromthe adsorption results, we can find that Langmuir is the most fittedadsorption isotherm model and the pseudo-second order model best fittedthe adsorption kinetics. The energy of activation for adsorption,which was determined to be 15.23 kJ/mol, also supported a chemisorptionprocess. The mechanism of adsorption was evaluated, and details ofall possible interactions between DOX and Ag-MOF were illustrated.On the other hand, while examining the impact of temperature, we identifiedthe thermodynamic constraints as & UDelta;G & DEG;,& UDelta;H & DEG;, and & UDelta;S & DEG;and confirmed that the reaction was an endothermic one and spontaneous.Even after numerous reuse cycles, the efficiency remained constant.The synthetic adsorbent was remarkably recyclable at a rate of morethan 91.6%. By using the MTT assay, the cytotoxicity of the testedAg-MOF and DOX@Ag-MOF against human breast cancer cells (MCF-7) wasevaluated in vitro. The in vitro antimicrobial activity of Ag-MOF and DOX@Ag-MOF was also tested.