A novel near-infrared fluorescence probe for hydrogen sulfide detection and application in cell and mice imaging

被引：14

作者：

Gu, Xin ^{[1
]}

Yun, Luyao ^{[2
]}

Chen, Kaiqiang ^{[1
]}

He, Shu ^{[1
]}

Cheng, Pengfei ^{[1
]}

Xu, Kuoxi ^{[1
]}

机构：

[1] Henan Univ, Coll Chem & Mol Sci, Henan Engn Res Ctr Ind Recirculating Water Treatme, Kaifeng 475004, Henan, Peoples R China

[2] Henan Univ, Inst Pharm, Kaifeng 475004, Henan, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1286卷

关键词：

NIR-fluorescent probe; Large Stokes shift; Exogenous; endogenous H 2 S; H 2 S image in living cells and mice; LARGE STOKES SHIFT; LIVING CELLS; BIOIMAGING APPLICATION; SENSITIVE DETECTION; H2S; MITOCHONDRIA; SENSOR; RED;

D O I：

10.1016/j.molstruc.2023.135576

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We presented here a novel near-infrared fluorescent probe based on 2-(2 '-hydroxyphenyl)benzothiazole-dicyanoisophorone as fluorophore and 2,4-dinitrobenzenesulfonyl moiety as detection functionalized group for the discrimination of hydrogen sulfide (H2S). Probe L exhibited good specificity and sensitivity "turn on" response at 720 nm with a large Stokes shift (155 nm), rapid response (<60 s) and low detection limit (3.15 x 10- 7 M), which also could be identified by the naked eyes. Moreover, probe L was successfully used to image exogenous/endogenous H2S in cells and mice, which demonstrated its potential applications in living systems.

引用

页数：7

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