First Results from a Phase 1, First-in-Human Study of the Bruton's Tyrosine Kinase (BTK) Degrader Bgb-16673 in Patients (Pts) with Relapsed or Refractory (R/R) B-Cell Malignancies (BGB-16673-101)

被引：41

作者：

Seymour, John F. ^{[1
,2
]}

Cheah, Chan Yoon ^{[3
,4
,5
,6
,7
]}

Parrondo, Ricardo ^{[8
]}

Thompson, Meghan C. ^{[9
]}

Stevens, Don A. ^{[10
]}

Lasica, Masa ^{[11
]}

Wang, Michael L. ^{[12
]}

Kumar, Abhijeet ^{[13
]}

Trotman, Judith ^{[14
]}

Alwan, Maan ^{[15
]}

Ding, Wei ^{[16
]}

By, Kunthel ^{[17
]}

Tariq, Bilal ^{[17
]}

Chen, Xiangmei ^{[18
]}

Fabre, Shannon ^{[17
]}

Paik, Jason ^{[17
]}

Agarwal, Amit ^{[19
]}

Tam, Constantine S. ^{[20
,21
]}

机构：

[1] Royal Melbourne Hosp, Peter Maccallum Canc Ctr, Melbourne, Australia

[2] Univ Melbourne, Melbourne, Australia

[3] Sir Charles Gairdner Hosp, Dept Haematol, Nedlands, WA, Australia

[4] Pathwest Lab Med, Nedlands, WA, Australia

[5] Univ Western Australia, Med Sch, Crawley, WA, Australia

[6] Linear Clin Res, Nedlands, WA, Australia

[7] Sir Charles Gairdner Hosp, Nedlands, WA, Australia

[8] Mayo Clin, Jacksonville, FL USA

[9] Mem Sloan Kettering Canc Ctr, New York, NY USA

[10] Norton Canc Inst, Louisville, KY USA

[11] St Vincents Hosp Melbourne, Dept Haematol, Fitzroy, Vic, Australia

[12] MD Anderson Canc Ctr, Houston, TX USA

[13] Univ Arizona Coll Med Tucson, Tucson, AZ USA

[14] Univ Sydney, Concord Repatriat Gen Hosp, Concord, NSW, Australia

[15] Perth Blood Inst, Perth, WA, Australia

[16] Mayo Clin Rochester, Rochester, MN USA

[17] BeiGene USA Inc, San Mateo, CA USA

[18] BeiGene Shanghai Co Ltd, Shanghai, Peoples R China

[19] BeiGene, San Mateo, CA USA

[20] Alfred Hosp, Melbourne, Vic, Australia

[21] Monash Univ, Clayton, Vic, Australia

来源：

BLOOD | 2023年 / 142卷

关键词：

D O I：

10.1182/blood-2023-180109

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：6