LncRNA CTBP1-AS2 Influences Cellular Activities via miR-381-3p/ID1 Axis in Breast Cancer

LncRNAs are involved in a variety of physiological and pathological processes. Whereas, the putative role of lncRNAs in breast cancer remains largely elusive. Herein, we investigated the influence of lncRNA CTBP1-AS2 in breast cancer. The expression of lncRNA CTBP1-AS2 was detected in breast cancer tissues. The possible clinical value of CTBP1-AS2 was evaluated using the Kaplan-Meier curve. The influences of CTBP1-AS2 on tumor cell abilities were determined by in vitro experiments. Online databases and dual-luciferase reporter assay were used to reveal the interaction between CTBP1-AS2, miR-381-3p, and ID1. LncRNA CTBP1-AS2 expression showed rising trend in breast cancer tissues and forecasted a poor survival outcome in breast cancer patients. Functionally, CTBP1-AS2 knockdown inhibited tumor cell growth and invasion in vitro. Mechanistically, CTBP1-AS2 may competitively bind with miR-381-3p and then regulate ID1 to act as a tumor-promoter in breast cancer. Collectively, these results reveal the potential role of lncRNA CTBP1-AS2 in breast cancer and a novel CTBP1-AS2/miR-381-3p/ID1 pathway for tumor progression and suggest that CTBP1-AS2 may be a potential prognostic predictor and therapeutic target for patients with breast cancer.