New Insights into the Genetics and Epigenetics of Aging Plasticity

被引：8
作者：
Zhang, Jie [1 ]
Wang, Shixiao [1 ]
Liu, Baohua [1 ,2 ]
机构：
[1] Shenzhen Univ, Sch Basic Med Sci, Shenzhen Key Lab Syst Aging & Intervent SKL SAI, Shenzhen 518000, Peoples R China
[2] Shenzhen Univ, Sch Basic Med Sci, Med Sch, Guangdong Key Lab Genome Stabil & Human Dis Preven, Lihu Campus, Shenzhen 518000, Peoples R China
来源：
GENES | 2023年 / 14卷 / 02期
关键词：
healthy aging; senescence; genetics; epigenetics; epitranscriptome; LIFE-SPAN; STEM-CELLS; SENESCENT CELLS; CALORIE RESTRICTION; TISSUE HOMEOSTASIS; WERNER-SYNDROME; DOUBLE-BLIND; DNA-REPAIR; LAMIN; HETEROCHROMATIN;
D O I：
10.3390/genes14020329
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Biological aging is characterized by irreversible cell cycle blockade, a decreased capacity for tissue regeneration, and an increased risk of age-related diseases and mortality. A variety of genetic and epigenetic factors regulate aging, including the abnormal expression of aging-related genes, increased DNA methylation levels, altered histone modifications, and unbalanced protein translation homeostasis. The epitranscriptome is also closely associated with aging. Aging is regulated by both genetic and epigenetic factors, with significant variability, heterogeneity, and plasticity. Understanding the complex genetic and epigenetic mechanisms of aging will aid the identification of aging-related markers, which may in turn aid the development of effective interventions against this process. This review summarizes the latest research in the field of aging from a genetic and epigenetic perspective. We analyze the relationships between aging-related genes, examine the possibility of reversing the aging process by altering epigenetic age.
引用
收藏
页数：19
相关论文
共 155 条
  • [1] cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
    Ablasser, Andrea
    Goldeck, Marion
    Cavlar, Taner
    Deimling, Tobias
    Witte, Gregor
    Roehl, Ingo
    Hopfner, Karl-Peter
    Ludwig, Janos
    Hornung, Veit
    [J]. NATURE, 2013, 498 (7454) : 380 - +
  • [2] Mitochondrial and metabolic dysfunction in ageing and age-related diseases
    Amorim, Joao A.
    Coppotelli, Giuseppe
    Rolo, Anabela P.
    Palmeira, Carlos M.
    Ross, Jaime M.
    Sinclair, David A.
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2022, 18 (04) : 243 - 258
  • [3] Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
    Anderson, RM
    Bitterman, KJ
    Wood, JG
    Medvedik, O
    Sinclair, DA
    [J]. NATURE, 2003, 423 (6936) : 181 - 185
  • [4] The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
    Andreux, Penelope A.
    Blanco-Bose, William
    Ryu, Dongryeol
    Burdet, Frederic
    Ibberson, Mark
    Aebischer, Patrick
    Auwerx, Johan
    Singh, Anurag
    Rinsch, Chris
    [J]. NATURE METABOLISM, 2019, 1 (06) : 595 - 603
  • [5] Acetylation of Cytidine in mRNA Promotes Translation Efficiency
    Arango, Daniel
    Sturgill, David
    Alhusaini, Najwa
    Dillman, Allissa A.
    Sweet, Thomas J.
    Hanson, Gavin
    Hosogane, Masaki
    Sinclair, Wilson R.
    Nanan, Kyster K.
    Mandler, Mariana D.
    Fox, Stephen D.
    Zengeya, Thomas T.
    Andresson, Thorkell
    Meier, Jordan L.
    Coller, Jeffery
    Oberdoerffer, Shalini
    [J]. CELL, 2018, 175 (07) : 1872 - +
  • [6] A multidimensional systems biology analysis of cellular senescence in aging and disease
    Avelar, Roberto A.
    Ortega, Javier Gomez
    Tacutu, Robi
    Tyler, Eleanor J.
    Bennett, Dominic
    Binetti, Paolo
    Budovsky, Arie
    Chatsirisupachai, Kasit
    Johnson, Emily
    Murray, Alex
    Shields, Samuel
    Tejada-Martinez, Daniela
    Thornton, Daniel
    Fraifeld, Vadim E.
    Bishops, Cleo L.
    de Magalhaes, Joao Pedro
    [J]. GENOME BIOLOGY, 2020, 21 (01)
  • [7] Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
    Baar, Marjolein P.
    Brandt, Renata M. C.
    Putavet, Diana A.
    Klein, Julian D. D.
    Derks, Kasper W. J.
    Bourgeois, Benjamin R. M.
    Stryeck, Sarah
    Rijksen, Yvonne
    van Willigenburg, Hester
    Feijtel, Danny A.
    van der Pluijm, Ingrid
    Essers, Jeroen
    van Cappellen, Wiggert A.
    van IJcken, Wilfred F.
    Houtsmuller, Adriaan B.
    Pothof, Joris
    de Bruin, Ron W. F.
    Madl, Tobias
    Hoeijmakers, Jan H. J.
    Campisi, Judith
    de Keizer, Peter L. J.
    [J]. CELL, 2017, 169 (01) : 132 - +
  • [8] Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome
    Balmus, Gabriel
    Larrieu, Delphine
    Barros, Ana C.
    Collins, Casey
    Abrudan, Monica
    Demir, Mukerrem
    Geisler, Nicola J.
    Lelliott, Christopher J.
    White, Jacqueline K.
    Karp, Natasha A.
    Atkinson, James
    Kirton, Andrea
    Jacobsen, Matt
    Clift, Dean
    Rodriguez, Raphael
    Adams, David J.
    Jackson, Stephen P.
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [9] Baylis Daniel, 2013, Longev Healthspan, V2, P8, DOI 10.1186/2046-2395-2-8
  • [10] Epigenetic regulation of ageing: linking environmental inputs to genomic stability
    Benayoun, Berenice A.
    Pollina, Elizabeth A.
    Brunet, Anne
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (10) : 593 - 610
12345678910