Children's Oncology Group's 2023 blueprint for research: Renal tumors

被引：13

作者：

Geller, James L. ^{[1
]}

Hong, Andrew L. ^{[2
]}

Vallance, Kelly L. ^{[3
]}

Evageliou, Nick ^{[4
]}

Aldrink, Jennifer H. ^{[5
]}

Cost, Nicholas G. ^{[6
,7
,8
]}

Treece, Amy L. ^{[9
]}

Renfro, Lindsay A. ^{[10
]}

Mullen, Elizabeth A. ^{[11
]}

机构：

[1] Univ Cincinnati, Cincinnati Childrens Hosp, Div Oncol, Med Ctr, Cincinnati, OH 45221 USA

[2] Emory Univ, Aflac Canc & Blood Disorders Ctr, Childrens Healthcare Atlanta, Sch Med, Atlanta, GA USA

[3] Cook Childrens Med Ctr, Hematol & Oncol, Ft Worth, TX USA

[4] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA USA

[5] Ohio State Univ, Nationwide Childrens Hosp, Dept Surg, Div Pediat Surg,Coll Med, Columbus, OH USA

[6] Univ Colorado, Sch Med, Dept Surg, Div Urol, Aurora, CO USA

[7] Univ Colorado, Childrens Hosp Colorado, Surg Oncol Program, Sch Med, Aurora, CO USA

[8] Univ Colorado, Surg Oncol Program, Sch Med, Childrens Hosp Colorado, Aurora, CO USA

[9] Childrens Alabama, Dept Pathol & Lab Med, Birmingham, AL USA

[10] USC, Keck Sch Med, Los Angeles, CA USA

[11] Dana Farber Boston Childrens Blood Disorders & Ca, Boston, MA USA

来源：

PEDIATRIC BLOOD & CANCER | 2023年 / 70卷

基金：

美国国家卫生研究院;

关键词：

clear cell sarcoma; renal; rhabdoid tumor; tumors; Wilms tumor; MALIGNANT RHABDOID TUMORS; HISTOLOGY WILMS-TUMOR; PEDIATRIC-PATIENTS; INITIAL TREATMENT; ACTINOMYCIN-D; VINCRISTINE; DOXORUBICIN; MUTATIONS; SURVIVORS; FAILURE;

D O I：

10.1002/pbc.30586

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Every year, approximately 600 infants, children, and adolescents are diagnosed with renal cancer in the United States. In addition to Wilms tumor (WT), which accounts for about 80% of all pediatric renal cancers, clear cell sarcoma of the kidney, renal cell carcinoma, malignant rhabdoid tumor, as well as more rare cancers (other sarcomas, rare carcinomas, lymphoma) and benign tumors can originate within the kidney. WT itself can be divided into favorable histology (FHWT), with a 5-year overall survival (OS) exceeding 90%, and anaplastic histology, with 4-year OS of 73.7%. Outcomes of the other pediatric renal cancers include clear cell sarcoma (5-year OS: 90%), malignant rhabdoid tumor (5-year OS: 10% for stages 3 and 4), and renal cell carcinoma (4-year OS: 84.8%). Recent clinical trials have identified novel biological prognostic markers for FHWT, and a series of Children's Oncology Group (COG) trials have demonstrated improving outcomes with therapy modification, and opportunities for further care refinement.

引用

页数：9

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