Long-Term Care and Follow-Up in Laryngeal Cancer Patients: A Multicenter Retrospective Analysis

被引：3

作者：

Marijic, Blazen ^{[1
,2
,3
]}

Tudor, Filip ^{[2
,3
]}

Janik, Stefan ^{[4
]}

Grasl, Stefan ^{[4
]}

Frommlet, Florian ^{[5
]}

Marzic, Diana ^{[3
,6
]}

Hadzisejdic, Ita ^{[3
,7
]}

Vukelic, Jelena ^{[3
,6
]}

Braut, Tamara ^{[2
,3
]}

Velepic, Marko ^{[2
,3
]}

Erovic, Boban M. ^{[1
]}

机构：

[1] Evangel Hosp, Inst Head & Neck Dis, A-1180 Vienna, Austria

[2] Clin Hosp Ctr Rijeka, Dept Otorhinolaryngol Head & Neck Surg, Rijeka 51000, Croatia

[3] Univ Rijeka, Fac Med, Rijeka 51000, Croatia

[4] Med Univ Vienna, Dept Otorhinolaryngol Head & Neck Surg, A-1090 Vienna, Austria

[5] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Sect Med Stat, A-1090 Vienna, Austria

[6] Clin Hosp Ctr Rijeka, Dept Audiol & Phoniatr, Rijeka 51000, Croatia

[7] Clin Hosp Ctr Rijeka, Clin Dept Pathol & Cytol, Rijeka 51000, Croatia

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 06期

关键词：

long-term care and follow-up; laryngeal carcinoma; secondary primary tumor; recurrence; survival; 2ND PRIMARY TUMORS; NECK-CANCER; HEAD; MALIGNANCIES; METASTASES; SURVEILLANCE; CARCINOMA; TRACT;

D O I：

10.3390/jpm13060927

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Purpose: We conducted an outcome analysis on surgically treated laryngeal squamous cell carcinoma (LSCC) patients. Methods: A multicenter retrospective study with 352 patients was analyzed. A new nomogram that incorporates age, T- and N-classification, and treatment was created. Results: Recurrence was observed in 65 (18.5%) patients after a mean time of 16.5 months. After 60 months, 91 (25.9%) of patients developed secondary primary tumors (SPT), most commonly in the lungs (n = 29; 8.2%) followed by other head and neck cancers (n = 21; 6.0%). Notably, the mean time to occurrence of secondary head and neck cancers was twice that of lung cancer (101.1 vs. 47.5 months). Conclusion: Recurrent disease is less common in LSCC patients and appears much earlier than SPT. Because one in every four laryngeal cancer patients develops SPTs within 5-10 years, long-term care and follow-up, including imaging studies, are highly recommended. The nomogram was useful for estimating survival.

引用

页数：13

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