ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells

被引：4

作者：

Lafita-Navarro, M. Carmen ^{[1
]}

Hao, Yi-Heng ^{[1
]}

Jiang, Chunhui ^{[1
]}

Jang, Seoyeon ^{[2
]}

Chang, Tsung-Cheng ^{[2
]}

Brown, Isabella N. ^{[1
]}

Venkateswaran, Niranjan ^{[1
]}

Maurais, Elizabeth ^{[1
]}

Stachera, Weronika ^{[1
]}

Zhang, Yanfeng ^{[3
,4
]}

Mundy, Dorothy ^{[1
,5
]}

Han, Jungsoo ^{[2
]}

Tran, Vanna M. ^{[1
]}

Mettlen, Marcel ^{[1
]}

Xu, Lin ^{[3
,4
]}

Woodruff, Jeffrey B. ^{[1
]}

V. Grishin, Nick ^{[7
,9
]}

Kinch, Lisa ^{[7
,9
]}

Mendell, Joshua T. ^{[2
,6
,7
,8
]}

Buszczak, Michael ^{[2
]}

Conacci-Sorrell, Maralice ^{[1
,6
,8
]}

机构：

[1] Univ Texas Southwestern Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr, Quantitat Biomed Res Ctr, Peter ODonnell Jr Sch Publ Hlth, Dept Populat & Data Sci, Dallas, TX 75390 USA

[4] Univ Texas Southwestern Med Ctr, Dept Pediat, Dallas, TX 75390 USA

[5] Univ Texas Southwestern Med Ctr, Live Cell Imaging Core Facil, Dallas, TX 75390 USA

[6] Univ Texas Southwestern Med Ctr, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

[7] Univ Texas Southwestern Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA

[8] Univ Texas Southwestern Med Ctr, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

[9] Univ Texas Southwestern Med Ctr, Dept Biophys, Dallas, TX 75390 USA

来源：

CELL REPORTS | 2023年 / 42卷 / 10期

基金：

美国国家科学基金会;

关键词：

C-MYC; RNA; BIOGENESIS; TRANSCRIPTION; PROCESSOME; INITIATION; CANCER; ITS1;

D O I：

10.1016/j.celrep.2023.113280

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRNAs. Here, we report the identification of the zinc finger protein 692 (ZNF692), a MYC-induced nucleolar scaffold that coordinates the final steps in the biogenesis of the small ribosome subunit. ZNF692 forms a hub containing the exosome complex and ribosome biogenesis factors specialized in the final steps of 18S rRNA processing and 40S ribosome maturation in the granular component of the nucleolus. Highly proliferative cells are more reliant on ZNF692 than normal cells; thus, we conclude that effective production of small ribosome subunits is critical for translation efficiency in cancer cells.

引用

页数：24