Understanding PPARγ and Its Agonists on Trophoblast Differentiation and Invasion: Potential Therapeutic Targets for Gestational Diabetes Mellitus and Preeclampsia

被引:7
作者
Qin, Yushu [1 ]
Bily, Donalyn [1 ,2 ]
Aguirre, Makayla [1 ]
Zhang, Ke [1 ,3 ]
Xie, Linglin [1 ]
机构
[1] Texas A&M Univ, Dept Nutr, College Stn, TX 77843 USA
[2] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA
[3] Texas A&M Univ, Inst Biosci & Technol, Houston, TX 77030 USA
关键词
PPAR gamma; rosiglitazone; trophoblast; placenta; gestational diabetes mellitus; preeclampsia; pregnancy; ACTIVATED-RECEPTOR-GAMMA; BLOCKS ADIPOCYTE DIFFERENTIATION; PLACENTAL DEVELOPMENT; ALPHA HETERODIMERS; INSULIN-RESISTANCE; ENDOGENOUS LIGAND; ADIPOSE-TISSUE; GLUCOSE-UPTAKE; EXPRESSION; ROSIGLITAZONE;
D O I
10.3390/nu15112459
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The increasing incidence of pregnancy complications, particularly gestational diabetes mellitus (GDM) and preeclampsia (PE), is a cause for concern, as they can result in serious health consequences for both mothers and infants. The pathogenesis of these complications is still not fully understood, although it is known that the pathologic placenta plays a crucial role. Studies have shown that PPAR?, a transcription factor involved in glucose and lipid metabolism, may have a critical role in the etiology of these complications. While PPAR? agonists are FDA-approved drugs for Type 2 Diabetes Mellitus, their safety during pregnancy is not yet established. Nevertheless, there is growing evidence for the therapeutic potential of PPAR? in the treatment of PE using mouse models and in cell cultures. This review aims to summarize the current understanding of the mechanism of PPAR? in placental pathophysiology and to explore the possibility of using PPAR? ligands as a treatment option for pregnancy complications. Overall, this topic is of great significance for improving maternal and fetal health outcomes and warrants further investigation.
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页数:15
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