Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

被引：6

作者：

Castedo, Maria ^{[1
,2
]}

Lafarge, Antoine ^{[1
,2
,3
]}

Kroemer, Guido ^{[1
,2
,4
]}

机构：

[1] Sorbonne Univ, Univ Paris Cite, Ctr Rech Cordeliers, Equipe 11 Labellisee Ligue Canc,INSERM U1138, F-75006 Paris, France

[2] Metabol & Cell Biol Platforms, Gustave Roussy Canc Campus, Villejuif, France

[3] Univ Paris Saclay, Fac medecine, Le Kremlin Bicetre, France

[4] Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Inst Canc Paris CARPEM, Dept Biol, Paris, France

来源：

CELL STRESS | 2023年 / 7卷 / 01期

关键词：

PARP1; inhibition; DNA damage; parthanatos; cancer; neurological diseases; aging; cellular stress response; PARP; INHIBITION; NECROSIS; MITOCHONDRIAL; ACTIVATION; CISPLATIN; APOPTOSIS; ELEGANS;

D O I：

10.15698/cst2023.01.275

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhi-bition protects mice against cerebral ischemia and Parkin-son's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhi-bition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.

引用

页码：1 / 6

页数：6

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