Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

被引：6
作者：
Castedo, Maria [1 ,2 ]
Lafarge, Antoine [1 ,2 ,3 ]
Kroemer, Guido [1 ,2 ,4 ]
机构：
[1] Sorbonne Univ, Univ Paris Cite, Ctr Rech Cordeliers, Equipe 11 Labellisee Ligue Canc,INSERM U1138, F-75006 Paris, France
[2] Metabol & Cell Biol Platforms, Gustave Roussy Canc Campus, Villejuif, France
[3] Univ Paris Saclay, Fac medecine, Le Kremlin Bicetre, France
[4] Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Inst Canc Paris CARPEM, Dept Biol, Paris, France
来源：
CELL STRESS | 2023年 / 7卷 / 01期
关键词：
PARP1; inhibition; DNA damage; parthanatos; cancer; neurological diseases; aging; cellular stress response; PARP; INHIBITION; NECROSIS; MITOCHONDRIAL; ACTIVATION; CISPLATIN; APOPTOSIS; ELEGANS;
D O I：
10.15698/cst2023.01.275
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhi-bition protects mice against cerebral ischemia and Parkin-son's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhi-bition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.
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页码：1 / 6
页数：6
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