Phomopsischalins A-C, polycyclic-fused cytochalasins from the endophytic fungus Phomopsis sp. shj2 and their abilities to induce lysosomal function

被引：7

作者：

Chen, Rong ^{[1
,2
]}

Guo, Li-Jing ^{[3
]}

Li, Xue-Dan ^{[3
]}

Li, Xing-Ren ^{[1
,2
]}

Hu, Kun ^{[1
,2
]}

Tang, Jian-Wei ^{[1
,2
]}

Ye, Zhen-Nan ^{[3
]}

Yan, Bing-Chao ^{[1
,2
]}

Puno, Pema-Tenzin ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources Wes, Kunming 650201, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China

[3] Guangdong Med Univ, Guangdong Prov Key Lab Autophagy & Major Chron Non, Affiliated Hosp, Zhanjiang 524001, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Dichroism - Fungi - Transcription - X ray powder diffraction;

D O I：

10.1039/d3qo00252g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phomopsischalins A (1) and B (2), two unprecedented cytochalasins featuring a 5/6/6/7-fused tetracyclic ring system, and phomopsischalin C (3), bearing a 5/6/5/8-fused tetracyclic ring system, were isolated from the endophytic fungus Phomopsis sp. shj2. Their structures were elucidated by extensive spectroscopic analysis, electronic circular dichroism (ECD), and single X-ray diffraction analysis. Compound 2 promoted lysosomal function independent of the transcriptional activity of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and function.

引用

页码：2218 / 2225

页数：8

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