Microwave-assisted rapid synthesis of chiral oxazolines

被引：3

作者：

Deng, Haowen ^{[1
,2
,3
,4
]}

Wang, Jianshe ^{[5
]}

He, Wei ^{[6
]}

Ye, Yang ^{[1
,2
,3
,4
]}

Bai, Renren ^{[1
,2
,3
,4
]}

Zhang, Xuelei ^{[1
,2
,3
,4
]}

Ye, Xiang-Yang ^{[1
,2
,3
,4
]}

Xie, Tian ^{[1
,2
,3
,4
]}

Hui, Zi ^{[1
,2
,3
,4
]}

机构：

[1] Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Zhejiang, Peoples R China

[2] Key Lab Elemene Class Anticanc Chinese Med Zhejian, Hangzhou, Peoples R China

[3] Engn Lab Dev & Applicat Tradit Chinese Med Zhejian, Hangzhou, Peoples R China

[4] Collaborat Innovat Ctr Chinese Med Zhejiang Prov, Hangzhou, Peoples R China

[5] Hangzhou PurpleCrystal Pharm Co Ltd, Drug Discovery, Hangzhou 311121, Zhejiang, Peoples R China

[6] Adlai Nortye Ltd, Chem Mfg & Control, Hangzhou 311121, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 11期

基金：

中国国家自然科学基金;

关键词：

BIS(OXAZOLINE) LIGANDS; CATALYSIS; DESIGN; ACID; HYDROSILYLATION; IMIDAZOLINES; VERSATILE; GLUTAMATE; ANALOGS; KETONES;

D O I：

10.1039/d2ob02192g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral oxazoline compounds play an extremely important role in asymmetric synthesis and drug discovery. Herein a simpler, greener and more efficient microwave-assisted protocol to rapidly access chiral oxazolines is developed using aryl nitriles or cyano-containing compounds and chiral beta-amino alcohols as starting materials. The reaction proceeds smoothly in the presence of a recoverable heterogeneous catalyst in either concentrated solution or under solvent-free conditions. The advantages of this method include rapidness, convenience, environmental protection, high atom economy, and excellent yields. The protocol should find wider application in the community in the future.

引用

页码：2312 / 2319

页数：9

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