Probiotics: insights and new opportunities for Clostridioides difficile intervention

被引：17
作者：
Pal, Rusha [1 ]
Athamneh, Ahmad I. M. [2 ]
Deshpande, Riddhi [3 ]
Ramirez, Jose A. R. [4 ]
Adu, Kayode T. [4 ,5 ]
Muthuirulan, Pushpanathan [6 ]
Pawar, Shrikant [7 ]
Biazzo, Manuele [8 ]
Apidianakis, Yiorgos [9 ]
Sundekilde, Ulrik Kraemer [10 ]
de la Fuente-Nunez, Cesar [11 ,12 ,13 ,14 ,15 ]
Martens, Mark G. [3 ,16 ]
Tegos, George P. [16 ]
Seleem, Mohamed N. [1 ,17 ]
机构：
[1] Virginia Polytech Inst & State Univ, Virginia Maryland Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA
[2] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA
[3] Reading Hosp, Tower Hlth, W Reading, PA USA
[4] James Cook Univ, ProbioWorld Consulting Grp, Townsville, Qld, Australia
[5] La Trobe Univ, Walter & Eliza Hall Inst, Cann Grp, Bundoora, Vic, Australia
[6] Harvard Univ, Dept Human Evolutionary Biol, Cambridge, MA 02138 USA
[7] Yale Sch Med, Anlyan Ctr, Yale Ctr Genom Anal, New Haven, CT USA
[8] Bioarte Ltd Labs, Life Sci Pk, San Gwann, Malta
[9] Univ Cyprus, Dept Biol Sci, Nicosia, Cyprus
[10] Aarhus Univ, Dept Food Sci, Aarhus, Denmark
[11] Univ Penn, Perelman Sch Med, Machine Biol Grp,Inst Translat Med & Therapeut, Inst Biomed Informat,Dept Psychiat, Philadelphia, PA 19104 USA
[12] Univ Penn, Perelman Sch Med, Machine Biol Grp,Inst Translat Med & Therapeut, Inst Biomed Informat,Dept Microbiol, Philadelphia, PA 19104 USA
[13] Univ Penn, Sch Engn & Appl Sci, Dept Bioengn, Philadelphia, PA 19104 USA
[14] Univ Penn, Sch Engn & Appl Sci, Dept Chem & Biomol Engn, Philadelphia, PA 19104 USA
[15] Univ Penn, Penn Inst Computat Sci, Philadelphia, PA 19104 USA
[16] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA
[17] Virginia Polytech Inst & State Univ, Ctr Emerging Zoonot & Arthropod Borne Pathogens, Blacksburg, VA 24061 USA
来源：
CRITICAL REVIEWS IN MICROBIOLOGY | 2023年 / 49卷 / 03期
关键词：
Probiotics; C; difficile; inhibition; virulence; immunomodulatory; genomic exploration; discovery informatics; metabolomics; multi-omics; regulatory requirements; ANTIBIOTIC-ASSOCIATED DIARRHEA; FECAL MICROBIOTA TRANSPLANTATION; LACTOBACILLUS-ACIDOPHILUS CL1285; INTESTINAL BARRIER FUNCTION; SACCHAROMYCES-BOULARDII; IN-VITRO; DOUBLE-BLIND; FAECALIBACTERIUM-PRAUSNITZII; PRIMARY PREVENTION; ESCHERICHIA-COLI;
D O I：
10.1080/1040841X.2022.2072705
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Clostridioides difficile infection (CDI) is a life-threatening disease caused by the Gram-positive, opportunistic intestinal pathogen C. difficile. Despite the availability of antimicrobial drugs to treat CDI, such as vancomycin, metronidazole, and fidaxomicin, recurrence of infection remains a significant clinical challenge. The use of live commensal microorganisms, or probiotics, is one of the most investigated non-antibiotic therapeutic options to balance gastrointestinal (GI) microbiota and subsequently tackle dysbiosis. In this review, we will discuss major commensal probiotic strains that have the potential to prevent and/or treat CDI and its recurrence, reassess the efficacy of probiotics supplementation as a CDI intervention, delve into lessons learned from probiotic modulation of the immune system, explore avenues like genome-scale metabolic network reconstructions, genome sequencing, and multi-omics to identify novel strains and understand their functionality, and discuss the current regulatory framework, challenges, and future directions.
引用
收藏
页码：414 / 434
页数：21
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