The Safety and Efficacy of Cryotherapy in the Prevention of Paclitaxel-Induced Neuropathy: A Systematic Review

被引:0
作者
Hossain, Md Fahad [1 ]
Kharel, Manish [2 ]
Rajib, Mostafa Hasan [3 ]
Khan, Mahfuza A. [4 ]
Anwar, Md. Yasin [5 ]
Lamsal, Yogesh [6 ]
Aziz, Syed Nurul [7 ,8 ]
机构
[1] Minist Hlth, Hosp Med, Upazila Hlth Complex, Kishoreganj, Bangladesh
[2] Jahurul Islam Med Coll & Hosp, Med & Surg, Bhagalpur, Bangladesh
[3] Bangabandhu Sheikh Mujib Med Univ BSMMU, Endocrinol, Dhaka, Bangladesh
[4] Sylhet MAG Muhammad Ataul Goni Osmani Med Coll, Internal Med, Sylhet, Bangladesh
[5] 250 Bed Dist Sadar Hosp, Cardiol, Cox Bazar, Bangladesh
[6] Sahara Hosp Pvt Ltd, Emergency Med, Pokhara, Nepal
[7] Univ Missouri, Obstet & Gynaecol, Columbia, MO USA
[8] Shaheed Suhrawardy Med Coll, Internal Med, Dhaka, Bangladesh
关键词
non-pharmacological interventions; cancer patients; paclitaxel; cryotherapy; peripheral neuropathy; INDUCED PERIPHERAL NEUROPATHY; BREAST-CANCER; TOLERABILITY; CIPN;
D O I
10.7759/cureus.44026
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The chemotherapeutic agent paclitaxel has significantly enhanced the treatment of various types of cancer. However, the quality of life of cancer patients is often impacted by the painful and dose-restrictive paclitaxel side effect known as paclitaxel-induced peripheral neuropathy (PIPN). A non-pharmacological method called cryotherapy has shown promise in alleviating PIPN-related symptoms. In this systematic review, we aimed to evaluate the safety and effectiveness of cryotherapy in preventing PIPN. The review analyzed four randomized controlled trials (RCTs) involving individuals treated with paclitaxel for breast and gynecological cancer. Cryotherapy showed success in lowering PIPN symptoms in several studies, as judged by various outcome measures, although the findings varied. The safety profile of cryotherapy was typically good, with minimal side effects. However, methodological variations and small sample sizes in the studies analyzed limit drawing definitive conclusions from them. To obtain conclusive evidence, studies with standardized techniques and larger sample sizes are required. Further research is necessary to understand cryotherapy's potential mechanisms and long-term effects. This review highlights the potential of cryotherapy in the management of PIPN, explains how it works, and suggests future research topics to improve its application.
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页数:10
相关论文
共 34 条
[31]  
Tsumuki H, 2001, RHEUMATOL INT, V20, P175
[32]   Efficacy of cryotherapy on chemotherapy-induced peripheral neuropathy in patients with breast cancer: a propensity score-matched study [J].
Xu, Min ;
Wang, Fan ;
Zhu, Xiaoli ;
Hao, Zhaohua .
ANNALS OF MEDICINE AND SURGERY, 2023, 85 (06) :2695-2703
[33]   Effect of cryotherapy on paclitaxel-induced peripheral neuropathy of the hand in female breast cancer patients: A prospective self-controlled study [J].
Yang, Ting-Ting ;
Pai, Hsiang-Chu ;
Chen, Chiung-Yao .
INTERNATIONAL JOURNAL OF NURSING PRACTICE, 2023, 29 (04)
[34]  
Yang Y, 2020, J Int Med Res, V48, P3, DOI [10.1177/0300060520929318, DOI 10.1177/0300060520929318]