Environmental Enrichment Promotes Transgenerational Programming of Uterine Inflammatory and Stress Markers Comparable to Gestational Chronic Variable Stress

被引:7
作者
Lopes, Nayara A. [1 ,2 ]
Ambeskovic, Mirela [3 ]
King, Stephanie E. [3 ]
Faraji, Jamshid [3 ]
Soltanpour, Nasrin [3 ]
Falkenberg, Erin A. [3 ]
Scheidl, Taylor [1 ]
Patel, Mansi [3 ]
Fang, Xin [1 ]
Metz, Gerlinde A. S. [1 ,3 ]
Olson, David M. [1 ,2 ,3 ,4 ]
机构
[1] Univ Alberta, Dept Obstet & Gynecol, Edmonton, AB T6G 2R3, Canada
[2] Univ Alberta, Dept Physiol, Edmonton, AB T6G 2R3, Canada
[3] Univ Lethbridge, Dept Neurosci, Lethbridge, AB T1K 3M4, Canada
[4] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2R3, Canada
基金
加拿大健康研究院;
关键词
chronic variable stress; pregnancy; uterus; prenatal stress; preterm birth; gene expression; inflammation; rodents; enriched environment; resilience; PRENATAL STRESS; MATERNAL STRESS; PSYCHOSOCIAL STRESS; CYTOKINE PRODUCTION; CELL-PROLIFERATION; PRETERM BIRTH; BRAIN SIZE; INCREASES; EXPOSURE; HIPPOCAMPUS;
D O I
10.3390/ijms24043734
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Prenatal maternal stress is linked to adverse pregnancy and infant outcomes, including shortened gestation lengths, low birth weights, cardio-metabolic dysfunction, and cognitive and behavioural problems. Stress disrupts the homeostatic milieu of pregnancy by altering inflammatory and neuroendocrine mediators. These stress-induced phenotypic changes can be passed on to the offspring epigenetically. We investigated the effects of gestational chronic variable stress (CVS) in rats using restraint and social isolation stress in the parental F0 generation and its transgenerational transmission across three generations of female offspring (F1-F3). A subset of F1 rats was housed in an enriched environment (EE) to mitigate the adverse effects of CVS. We found that CVS is transmitted across generations and induces inflammatory changes in the uterus. CVS did not alter any gestational lengths or birth weights. However, inflammatory and endocrine markers changed in the uterine tissues of stressed mothers and their offspring, suggesting that stress is transgenerationally transmitted. The F2 offspring reared in EE had increased birth weights, but their uterine gene expression patterns remained comparable to those of stressed animals. Thus, ancestral CVS induced changes transgenerationally in fetal programming of uterine stress markers over three generations of offspring, and EE housing did not mitigate these effects.
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页数:27
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