Divergent synthesis of nitrogen heterocycles via H2O-mediated hydride transfer reactions

被引：19
作者：
Hu, Fangzhi [1 ]
Sun, Zhipeng [1 ]
Pan, Mengzhe [1 ]
Wang, Liang [1 ]
Xu, Lubin [1 ]
Liu, Xiong-Li [2 ]
Li, Shuai-Shuai [1 ]
机构：
[1] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China
[2] Guizhou Univ, Natl & Local Joint Engn Res Ctr Exploitat Homol Re, Guiyang 550025, Peoples R China
来源：
GREEN CHEMISTRY | 2023年 / 25卷 / 13期
基金：
中国国家自然科学基金;
关键词：
C-H FUNCTIONALIZATION; C(SP(3))-H FUNCTIONALIZATION; DIASTEREOSELECTIVE SYNTHESIS; BOND; CONSTRUCTION; TETRAHYDROQUINOLINE; INHIBITORS; CYCLIZATION; PALLADIUM; OXIDATION;
D O I：
10.1039/d3gc00166k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The H2O-promoted controllable synthesis of diverse nitrogen heterocycles from readily available feedstocks was developed by a hydride transfer strategy. A variety of 3-carboxyl and 3-acyl substituted tetrahydroquinolines and 3,4-dihydroquinolin-2(1H)-ones were obtained via cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization/hydrolysis/decarboxylation and cascade Knoevenagel condensation/[1,5]-hydride transfer/N-dealkylation/N-acylation processes, respectively. In addition, the synthetic utility of the methodology and mechanistic studies were also well presented.
引用
收藏
页码：5134 / 5141
页数：8
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