Divergent synthesis of nitrogen heterocycles via H2O-mediated hydride transfer reactions

被引：24

作者：

Hu, Fangzhi ^{[1
]}

Sun, Zhipeng ^{[1
]}

Pan, Mengzhe ^{[1
]}

Wang, Liang ^{[1
]}

Xu, Lubin ^{[1
]}

Liu, Xiong-Li ^{[2
]}

Li, Shuai-Shuai ^{[1
]}

机构：

[1] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China

[2] Guizhou Univ, Natl & Local Joint Engn Res Ctr Exploitat Homol Re, Guiyang 550025, Peoples R China

来源：

GREEN CHEMISTRY | 2023年 / 25卷 / 13期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; C(SP(3))-H FUNCTIONALIZATION; DIASTEREOSELECTIVE SYNTHESIS; BOND; CONSTRUCTION; TETRAHYDROQUINOLINE; INHIBITORS; CYCLIZATION; PALLADIUM; OXIDATION;

D O I：

10.1039/d3gc00166k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The H2O-promoted controllable synthesis of diverse nitrogen heterocycles from readily available feedstocks was developed by a hydride transfer strategy. A variety of 3-carboxyl and 3-acyl substituted tetrahydroquinolines and 3,4-dihydroquinolin-2(1H)-ones were obtained via cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization/hydrolysis/decarboxylation and cascade Knoevenagel condensation/[1,5]-hydride transfer/N-dealkylation/N-acylation processes, respectively. In addition, the synthetic utility of the methodology and mechanistic studies were also well presented.

引用

页码：5134 / 5141

页数：8

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