Spinal dopaminergic D1-and D2-like receptors have a sex-dependent effect in an experimental model of fibromyalgia*

被引：5
作者：
De la Luz-Cuellar, Yarim Elideth [1 ]
Coffeen, Ulises [2 ]
Mercado, Francisco [3 ]
Granados-Soto, Vinicio [1 ,4 ]
机构：
[1] Cinvestav, Dept Farmacobiol, Neurobiol Pain Lab, South Campus, Mexico City, Mexico
[2] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Lab Neurofisiol Integrat, Direcc Invest Neurocienciasncias, Mexico City, Mexico
[3] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Lab Fisiol Celular, Direcc Invest Neurocienciasncias, Mexico City, Mexico
[4] Cinvestav, Dept Farmacobiol, Neurobiol Pain Lab, South Campus,Calz Tenorios 235, Mexico City 14330, Mexico
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2023年 / 948卷
关键词：
Dopamine D 1-like receptors; Dopamine D 2-like receptors; Fibromyalgia; Pain; Reserpine; SOCIAL INTERACTIONS; ESTROUS-CYCLE; PAIN; ESTRADIOL; ANTAGONISTS; EXPRESSION; NEURONS; PROGESTERONE; HYPERALGESIA; NOCICEPTION;
D O I：
10.1016/j.ejphar.2023.175696
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
There is evidence about the importance of sex in pain. The purpose of this study was to investigate the effect of sex in the antiallodynic activity of spinal dopamine D1-and D2-like receptors in a model of fibromyalgia-type pain in rats. Reserpine induced the same extent of tactile allodynia in female and male rats. Intrathecal injection of SCH-23390 (3-30 nmol, D1-like receptor antagonist), pramipexole (0.15-15 nmol) or quinpirole (1-10 nmol D2- like receptor agonists) increased withdrawal threshold in reserpine-treated female rats. Those drugs induced a greater antiallodynic effect in female rats. Sex-difference was also observed in a nerve injury model. Ovariectomy abated the antiallodynic effect of SCH-23390 (30 nmol) in reserpine-treated rats, while systemic reconstitution of 178-estradiol levels or intrathecal injection of estrogen receptor-alpha agonist protopanaxatriol in ovariectomized reserpine-treated females restored the antiallodynic effect of SCH-23390. Intrathecal administration of ICI-182,780 (estrogen receptor-alpha/8 antagonist) or methyl-piperidino-pyrazole hydrate (estrogen receptor-alpha antag-onist) abated 178-estradiol-restored antiallodynic effect of SCH-23390 in rats. In contrast, ovariectomy slightly reduced the effect of pramipexole (15 nmol) or quinpirole (10 nmol) in reserpine-treated rats, whereas systemic reconstitution of 178-estradiol levels did not modify the antiallodynic effect of both drugs. Combination 178-estradiol/progesterone, but not 178-estradiol nor progesterone alone, restored the antiallodynic effect of pra-mipexole and quinpirole in the rats. Mifepristone (progesterone receptor antagonist) abated 178-estradiol + progesterone restoration of the antiallodynic effect of pramipexole and quinpirole. These data suggest that the antiallodynic effect of dopamine D1-and D2-like receptors in fibromyalgia-type pain depends on spinal 178-estradiol/estrogen receptor-alpha and progesterone receptors, respectively.
引用
收藏
页数：10
相关论文
共 31 条
  • [1] Spinal dopaminergic D1 and D5 receptors contribute to reserpine-induced fibromyalgia-like pain in rats
    Elideth De la Luz-Cuellar, Yarim
    Josue Rodriguez-Palma, Erick
    Franco-Enzastiga, Urzula
    Deciga-Campos, Myrna
    Mercado, Francisco
    Granados-Soto, Vinicio
    [J]. BRAIN RESEARCH, 2023, 1799
  • [2] Role of D1-and D2-like dopamine receptors within the dentate gyrus in antinociception induced by chemical stimulation of the lateral hypothalamus in an animal model of acute pain
    Khaleghzadeh-Ahangar, Hossein
    Rashvand, Mina
    Haghparast, Abbas
    [J]. PHYSIOLOGY & BEHAVIOR, 2021, 229
  • [3] Role of D1-and D2-like dopaminergic receptors in the nucleus accumbens in modulation of formalin-induced orofacial pain: Involvement of lateral hypothalamus
    Shafiei, Iman
    Vatankhah, Mahsaneh
    Zarepour, Leila
    Ezzatpanah, Somayeh
    Haghparast, Abbas
    [J]. PHYSIOLOGY & BEHAVIOR, 2018, 188 : 25 - 31
  • [4] Differential Roles of the D1-and D2-Like Dopamine Receptors Within the Ventral Tegmental Area in Modulating the Antinociception Induced by Forced Swim Stress in the Rat
    Saghafi, Mohammad
    Danesh, Elaheh
    Askari, Reyhaneh
    Mousavi, Zahra
    Haghparast, Abbas
    [J]. NEUROCHEMICAL RESEARCH, 2024, 49 (01) : 143 - 156
  • [5] Coexpressed D1-and D2-Like Dopamine Receptors Antagonistically Modulate Acetylcholine Release in Caenorhabditis elegans
    Allen, Andrew T.
    Maher, Kathryn N.
    Wani, Khursheed A.
    Betts, Katherine E.
    Chase, Daniel L.
    [J]. GENETICS, 2011, 188 (03) : 579 - U153
  • [6] Contribution of D1-and D2-like dopamine receptors in the ventral tegmental area to the stress-induced analgesia in the animal model of acute pain
    Saghafi, Mohammad
    Danesh, Elaheh
    Ghalandari-Shamami, Mohadeseh
    Mousavi, Zahra
    Haghparast, Abbas
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2025, 487
  • [7] Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1-and D2-Like Receptors
    Bezu, Mekite
    Malikovic, Jovana
    Kristofova, Martina
    Engidawork, Ephrem
    Hoeger, Harald
    Lubec, Gert
    Korz, Volker
    [J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2017, 11
  • [8] MODULATION OF AMPA CURRENTS BY D1-LIKE BUT NOT D2-LIKE RECEPTORS IN SPINAL MOTONEURONS
    Han, P.
    Whelan, P. J.
    [J]. NEUROSCIENCE, 2009, 158 (04) : 1699 - 1707
  • [9] Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1-and D2-like receptors
    Auteri, Michelangelo
    Zizzo, Maria Grazia
    Amato, Antonella
    Serio, Rosa
    [J]. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2016, 73 (03) : 395 - 404
  • [10] Involvement of D1-and D2-Like Dopamine Receptors Within the Rat Nucleus Accumbens in the Maintenance of Morphine Rewarding Properties in the Rats
    Namvar, Parastoo
    Zarrabian, Shahram
    Nazari-Serenjeh, Farzaneh
    Sadeghzadeh, Fatemeh
    Haghparast, Abbas
    [J]. BEHAVIORAL NEUROSCIENCE, 2019, 133 (06) : 556 - 562
1234