Glucagon in type 2 diabetes: Friend or foe?

被引：14

作者：

Caruso, Irene ^{[1
]}

Marrano, Nicola ^{[1
]}

Biondi, Giuseppina ^{[1
]}

Genchi, Valentina Annamaria ^{[1
]}

D'Oria, Rossella ^{[1
]}

Sorice, Gian Pio ^{[1
]}

Perrini, Sebastio ^{[1
]}

Cignarelli, Angelo ^{[1
]}

Natalicchio, Annalisa ^{[1
]}

Laviola, Luigi ^{[1
]}

Giorgino, Francesco ^{[1
]}

机构：

[1] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Sect Internal Med Endocrinol Androl & Metab Dis, Bari, Italy

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2023年 / 39卷 / 03期

关键词：

cotadutide; diabetic kidney disease; dual agonists; glucagon; NAFLD; type; 2; diabetes; SPONTANEOUS MEAL SIZE; BROWN ADIPOSE-TISSUE; BETA-CELL FUNCTION; GLUCOSE-HOMEOSTASIS; INSULIN-SECRETION; GHRELIN SECRETION; POSTPRANDIAL HYPERGLYCEMIA; ENERGY-EXPENDITURE; PROTEIN-SYNTHESIS; SKELETAL-MUSCLES;

D O I：

10.1002/dmrr.3609

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperglucagonemia is one of the 'ominous' eight factors underlying the pathogenesis of type 2 diabetes (T2D). Glucagon is a peptide hormone involved in maintaining glucose homoeostasis by increasing hepatic glucose output to counterbalance insulin action. Long neglected, the introduction of dual and triple agonists exploiting glucagon signalling pathways has rekindled the interest in this hormone beyond its classic effect on glycaemia. Glucagon can promote weight loss by regulating food intake, energy expenditure, and brown and white adipose tissue functions through mechanisms still to be fully elucidated, thus its role in T2D pathogenesis should be further investigated. Moreover, the role of glucagon in the development of T2D micro- and macro-vascular complications is elusive. Mounting evidence suggests its beneficial effect in non-alcoholic fatty liver disease, while few studies postulated its favourable role in peripheral neuropathy and retinopathy. Contrarily, glucagon receptor agonism might induce renal changes resembling diabetic nephropathy, and data concerning glucagon actions on the cardiovascular system are conflicting. This review aims to summarise the available findings on the role of glucagon in the pathogenesis of T2D and its complications. Further experimental and clinical data are warranted to better understand the implications of glucagon signalling modulation with new antidiabetic drugs.

引用

页数：16