Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization

被引：17
作者：
Ma, Weiwei [1 ]
Zhou, Xiaohong [1 ]
Huang, Xin [1 ]
Xiong, Yong [1 ]
机构：
[1] Hubei Univ Chinese Med, Sch Acupuncture Moxibust & Orthoped, Wuhan 430061, Peoples R China
来源：
PLOS ONE | 2023年 / 18卷 / 10期
关键词：
INSULIN-RESISTANCE; OBESITY; OSTEOPOROSIS; ASSOCIATION; INSTRUMENTS; PREVALENCE; SCORE; BMI; FAT;
D O I：
10.1371/journal.pone.0290530
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
ObjectiveTo reveal the relationship between Body Mass Index(BMI), type 2 diabetes, and bone mineral density(BMD) using a mendelian randomization (MR) approach.MethodsGWAS data on BMI, type 2 diabetes, and BMD were selected from the IEU GWAS database at the University of Bristol.Univariable, multivariable, and mediated MR analyses were used to explore the relationship between BMI, type 2 diabetes, and BMD. beta(beta) values were given, and three methods, including inverse variance weighting, MR-Egger regression, and weighted median, were used in this analysis.ResultsUnivariable mendelian randomization (UVMR) results showed that BMI and type 2 diabetes were positively associated with BMD. However, the association between BMI and BMD was insignificant in the multivariable Mendelian randomization (MVMR) analysis, while that between type 2 diabetes and BMD remained significant. Mediated MR analysis indicated that type 2 diabetes mediated the regulation of BMD by BMI.ConclusionThis study provides evidence supporting a positive causal association between BMI, type 2 diabetes, and BMD. Type 2 diabetes acts as a mediator in the regulation of BMD by BMI, indicating that both BMI and type 2 diabetes exert a protective influence on BMD.
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页数：13
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