Comprehensive molecular understanding of pediatric acute myeloid leukemia

被引：9

作者：

Shiba, Norio ^{[1
]}

机构：

[1] Yokohama City Univ, Dept Pediat, Grad Sch Med, 3-9 Fukuura, Kanazawa Ku, Yokohama 2360004, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2023年 / 117卷 / 02期

关键词：

Pediatric AML; Minimal residual disease; Risk stratification; DNA methylation; ACUTE MEGAKARYOBLASTIC LEUKEMIA; MINIMAL RESIDUAL DISEASE; EVENT-FREE SURVIVAL; GEMTUZUMAB OZOGAMICIN; PROGNOSTIC IMPACT; POOR-PROGNOSIS; KIT MUTATIONS; DOWN-SYNDROME; RELAPSE RISK; EXPRESSION;

D O I：

10.1007/s12185-023-03533-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pediatric acute myeloid leukemia (AML) is a heterogeneous disease with various genetic abnormalities. Recent advances in genetic analysis have enabled the identification of causative genes in > 90% of pediatric AML cases. Fusion genes such as RUNX1::RUNX1T1, CBFB::MYH11, and KMT2A::MLLT3 are frequently detected in > 70% of pediatric AML cases, whereas FLT3-internal tandem duplication, CEBPA-bZip, and NPM1 mutations are detected in approximately 5-15% of cases, respectively. Conversely, mutations in DNMT3A, TET2, and IDH, which are common in adults, are extremely rare in pediatric AML. The genetic characteristics of pediatric AML are slightly different from those of adult AML. For accurate risk stratification and treatment intensity, genome analysis should be performed in a simple, fast, and inexpensive manner and the results should be returned to patients in real time. As with acute lymphoblastic leukemia, the presence or absence of minimal residual disease is an important factor in determining the success of treatment against AML, and it is important to predict prognosis and formulate treatment strategies considering the genetic abnormalities. For the development and clinical application of new molecularly targeted therapies based on identified genetic abnormalities, it is necessary to explore when and in which combinations drugs will be most effective.

引用

页码：173 / 181

页数：9

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