Quality-based design optimization is a process consisting of factor identification, finding an empirical/physical model between responses and factors, and finding a factor setting leading to the best quality levels. Response surface methodology is a well-grounded data-driven approach that applies a collection of statistical-mathematical techniques to achieve the design requirements. Today's complex systems are usually affected by nuisance factors and have more than one output characteristic with some degree of correlation. This study aims to develop two-stage stochastic programming for a multi-response optimization model based on the degree of conformance as the most comprehensive metric for such design problems. The proposed approach can include the model imprecision in the optimization procedure using the probabilistic properties of the estimated parameters. This method would be applied in highly sensitive processes or costly operations that require a more accurate setting to avoid extra reworks or scraps. A simulated annealing algorithm with a boosted scenario checking modification has been applied to cope with the expensive computations for problem instances with a large sample size of uncertain parameters. The proposed model has also analyzed two cases from the literature, and the results support its superiority compared to the existing approaches.
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