Application of microneedles combined with dendritic cell-targeted nanovaccine delivery system in percutaneous immunotherapy for triple-negative breast cancer

被引：7
作者：
Weng, Jiaqi [1 ]
Yang, Jing [1 ]
Wang, Weiwei [1 ]
Wen, Jiaoli [1 ]
Fang, Min [1 ]
Zheng, Gensuo [1 ]
Xie, Jing [2 ]
Zheng, Xi [3 ]
Feng, Lili [4 ]
Yan, Qinying [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
[2] Wenzhou Med Univ, Wenzhou Peoples Hosp, Clin Coll 3, Wenzhou 325000, Peoples R China
[3] Zhejiang Univ, Anal Ctr Agrobiol & Environm Sci, Hangzhou 310058, Peoples R China
[4] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Ophthalmol, Sch Med, Shanghai 200011, Peoples R China
来源：
NANOTECHNOLOGY | 2023年 / 34卷 / 47期
基金：
中国国家自然科学基金;
关键词：
nanovaccine; triple-negative breast cancer; percutaneous immunotherapy; DC targeted; CHITOSAN NANOPARTICLES; DISSOLVING MICRONEEDLES; TRANSDERMAL DELIVERY; ANTITUMOR IMMUNITY; DRUG; ADJUVANT; IMMUNOGENICITY; MICROSPHERES; VACCINATION; CHALLENGES;
D O I：
10.1088/1361-6528/ace97b
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
This work aims at developing a strategy to activate the antigen-presenting cells to enhance the effect of immunotherapy in triple-negative breast cancer (TNBC) through the dissolving microneedle patch (DMNP). In present study, mannosylated chitosan (MCS) nanoparticles (NPs) were designed to target dendritic cells (DCs), and the immunotherapy effect was enhanced by the adjuvant Bacillus Calmette-Guerin polysaccharide (BCG-PSN), achieving the purpose of transdermal immunotherapy for TNBC. Vaccination studies with mice demonstrated that MCS NPs effectively induce DCs maturation in the tumor-draining lymph nodes to stimulate strong immune responses in TNBC. Overall, chitosan-based DMNPs with complex adjuvant constituted a new potent transdermal vaccine delivery platform capable of exploiting more DCs in the skin for effective immunization.
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页数：12
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