Recent advances in microbial production of medium chain fatty acid from renewable carbon resources: A comprehensive review

被引：33

作者：

Ahn, Jung Ho ^{[1
,2
]}

Lim, Eui Seok ^{[1
,3
]}

Kim, Sang Min ^{[1
,3
]}

Han, Sung Ok ^{[3
]}

Um, Youngsoon ^{[1
,2
]}

机构：

[1] Korea Inst Sci & Technol, Clean Energy Res Ctr, 5 Hwarang Ro 14 Gil, Seoul, South Korea

[2] Univ Sci & Technol UST, KIST Sch, Div Energy & Environm Technol, 217 Gajeong Ro, Daejeon, South Korea

[3] Korea Univ, Dept Biotechnol, 145 Anam Ro, Seoul, South Korea

来源：

BIORESOURCE TECHNOLOGY | 2023年 / 381卷

基金：

新加坡国家研究基金会;

关键词：

Medium chain fatty acid; Chain elongation; Reverse beta-oxidation; Fatty acid synthesis; N-CAPROIC ACID; RUMINOCOCCACEAE BACTERIUM CPB6; BETA-OXIDATION REVERSAL; ESCHERICHIA-COLI; CLOSTRIDIUM-KLUYVERI; GENOME SEQUENCE; MCFA PRODUCTION; HEXANOIC ACID; ETHANOL; FERMENTATION;

D O I：

10.1016/j.biortech.2023.129147

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Microbial production of medium chain length fatty acids (MCFAs) from renewable resources is becoming increasingly important in establishing a sustainable and clean chemical industry. This review comprehensively summarizes current advances in microbial MCFA production from renewable resources. Detailed information is provided on two major MCFA production pathways using various renewable resources and other auxiliary pathways supporting MCFA production to help understand the fundamentals of bio-based MCFA production. In addition, conventional and well-studied MCFA producers are classified into two categories, natural and synthetic producers, and their characteristics on MCFA production are outlined. Moreover, various engineering strategies employed to achieve the highest MCFAs production up to date are showcased together with key enzymes suggested for MCFA overproduction. Finally, future challenges and perspectives are discussed towards more efficient production of bio-based MCFA production.

引用

页数：13

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