Porcine embryonic stem cells: An alternative solution for the shortage of human islets to treat type 1 diabetes?

被引：0
作者：
Nottle, Mark B. [1 ,2 ]
Vassiliev, Ivan [1 ,2 ]
Hawthorne, Wayne J. [3 ,4 ]
Cowan, Peter J. [5 ,6 ]
机构：
[1] Univ Adelaide, Robinson Res Inst, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Sch Biomed, Adelaide, SA 5005, Australia
[3] Westmead Inst Med Res, Ctr Transplant & Renal Res, Westmead, NSW, Australia
[4] Univ Sydney, Westmead Hosp, Sch Med Sci, Dept Surg, Westmead, NSW, Australia
[5] St Vincents Hosp, Immunol Res Ctr, Melbourne, Vic, Australia
[6] Univ Melbourne, Dept Med, Melbourne, Vic, Australia
来源：
XENOTRANSPLANTATION | 2024年 / 31卷 / 01期
关键词：
islet transplantation; porcine embryonic stem cells; type; 1; diabetes; IN-VITRO;
D O I：
10.1111/xen.12840
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Transplantation of human embryonic stem cell (ESC) derived beta-like cells and xenotransplantation of porcine islets are two potential cures for type 1 diabetes (T1D). We have previously reported the isolation of porcine ESCs and have also separately shown that islets from genetically modified pigs can effectively cure diabetes in a preclinical baboon model. Here we discuss the possibility of combining these technologies to produce gene-edited porcine ESC-derived islets as an alternative for treating T1D, which may offer several advantages compared with these approaches.
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页数：3
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