Porcine embryonic stem cells: An alternative solution for the shortage of human islets to treat type 1 diabetes?

被引：0

作者：

Nottle, Mark B. ^{[1
,2
]}

Vassiliev, Ivan ^{[1
,2
]}

Hawthorne, Wayne J. ^{[3
,4
]}

Cowan, Peter J. ^{[5
,6
]}

机构：

[1] Univ Adelaide, Robinson Res Inst, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Sch Biomed, Adelaide, SA 5005, Australia

[3] Westmead Inst Med Res, Ctr Transplant & Renal Res, Westmead, NSW, Australia

[4] Univ Sydney, Westmead Hosp, Sch Med Sci, Dept Surg, Westmead, NSW, Australia

[5] St Vincents Hosp, Immunol Res Ctr, Melbourne, Vic, Australia

[6] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

来源：

XENOTRANSPLANTATION | 2024年 / 31卷 / 01期

关键词：

islet transplantation; porcine embryonic stem cells; type; 1; diabetes; IN-VITRO;

D O I：

10.1111/xen.12840

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Transplantation of human embryonic stem cell (ESC) derived beta-like cells and xenotransplantation of porcine islets are two potential cures for type 1 diabetes (T1D). We have previously reported the isolation of porcine ESCs and have also separately shown that islets from genetically modified pigs can effectively cure diabetes in a preclinical baboon model. Here we discuss the possibility of combining these technologies to produce gene-edited porcine ESC-derived islets as an alternative for treating T1D, which may offer several advantages compared with these approaches.

引用

页数：3

共 50 条

[1] Mesenchymal stem cells to treat type 1 diabetes
Pixley, John S.
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2020, 1866 (04):
[2] Using stem cells to study and possibly treat type 1 diabetes
Melton, D. A.
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2011, 366 (1575) : 2307 - 2311
[3] Mast cells infiltrate pancreatic islets in human type 1 diabetes
Martino, Luisa
Masini, Matilde
Bugliani, Marco
Marselli, Lorella
Suleiman, Mara
Boggi, Ugo
Nogueira, Tatiane C.
Filipponi, Franco
Occhipinti, Margherita
Campani, Daniela
Dotta, Francesco
Syed, Farooq
Eizirik, Decio L.
Marchetti, Piero
De Tata, Vincenzo
[J]. DIABETOLOGIA, 2015, 58 (11) : 2554 - 2562
[4] Delivery of Dissociated Islets Cells within Microporous Annealed Particle Scaffold to Treat Type 1 Diabetes
Roosa, Colleen A.
Ma, Mingyang
Chhabra, Preeti
Brayman, Kenneth
Griffin, Donald
[J]. ADVANCED THERAPEUTICS, 2022, 5 (09)
[5] Human embryonic stem cells as an in vitro model for studying developmental origins of type 2 diabetes
Chen, Andy Chun-Hang
Lee, Kai Fai
Yeung, William Shu Biu
Lee, Yin Lau
[J]. WORLD JOURNAL OF STEM CELLS, 2020, 12 (08): : 761 - 775
[6] Gene expression analysis of human islets in a subject at onset of type 1 diabetes
Hopfgarten, Johan
Stenwall, Per-Anton
Wiberg, Anna
Anagandula, Mahesh
Ingvast, Sofie
Rosenling, Therese
Korsgren, Olle
Skog, Oskar
[J]. ACTA DIABETOLOGICA, 2014, 51 (02) : 199 - 204
[7] Pancreatic stem cells: building blocks for a better surrogate islet to treat type 1 diabetes
Peck, AB
Chaudhari, M
Cornelius, JG
Ramiya, VK
[J]. ANNALS OF MEDICINE, 2001, 33 (03) : 186 - 192
[8] β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells
Sui, Lina
Danzl, Nichole
Campbell, Sean R.
Viola, Ryan
Williams, Damian
Xing, Yuan
Wang, Yong
Phillips, Neil
Poffenberger, Greg
Johannesson, Bjarki
Oberholzer, Jose
Powers, Alvin C.
Leibel, Rudolph L.
Chen, Xiaojuan
Sykes, Megan
Egli, Dieter
[J]. DIABETES, 2018, 67 (01) : 26 - 35
[9] Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes
Goswami, Debkalpa
Domingo-Lopez, Daniel A.
Ward, Niamh A.
Millman, Jeffrey R.
Duffy, Garry P.
Dolan, Eimear B.
Roche, Ellen T.
[J]. ADVANCED SCIENCE, 2021, 8 (16)
[10] Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes
Vija, L.
Farge, D.
Gautier, J. -F.
Vexiau, P.
Dumitrache, C.
Bourgarit, A.
Verrecchia, F.
Larghero, J.
[J]. DIABETES & METABOLISM, 2009, 35 (02) : 85 - 93

← 1 2 3 4 5 →