Sleep-A brain-state serving systems memory consolidation

被引：101

作者：

Brodt, Svenja ^{[1
,2
]}

Inostroza, Marion ^{[1
]}

Niethard, Niels ^{[1
]}

Born, Jan ^{[1
,3
]}

机构：

[1] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany

[2] Max Planck Inst Biol Cybernet, Tubingen, Germany

[3] Univ Tubingen, Werner Reichert Ctr Integrat Neurosci, Tubingen, Germany

来源：

NEURON | 2023年 / 111卷 / 07期

基金：

欧洲研究理事会;

关键词：

SHARP-WAVE RIPPLES; HIPPOCAMPAL PLACE CELLS; SLOW OSCILLATIONS; REM-SLEEP; LOCUS-COERULEUS; PREFRONTAL CORTEX; EPISODIC MEMORY; ENHANCES MEMORY; BEHAVIORAL SEQUENCES; ASSEMBLY PATTERNS;

D O I：

10.1016/j.neuron.2023.03.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although long-term memory consolidation is supported by sleep, it is unclear how it differs from that during wakefulness. Our review, focusing on recent advances in the field, identifies the repeated replay of neuronal firing patterns as a basic mechanism triggering consolidation during sleep and wakefulness. During sleep, memory replay occurs during slow-wave sleep (SWS) in hippocampal assemblies together with ripples, thalamic spindles, neocortical slow oscillations, and noradrenergic activity. Here, hippocampal replay likely favors the transformation of hippocampus-dependent episodic memory into schema-like neocortical mem-ory. REM sleep following SWS might balance local synaptic rescaling accompanying memory transformation with a sleep-dependent homeostatic process of global synaptic renormalization. Sleep-dependent memory transformation is intensified during early development despite the immaturity of the hippocampus. Overall, beyond its greater efficacy, sleep consolidation differs from wake consolidation mainly in that it is supported, rather than impaired, by spontaneous hippocampal replay activity possibly gating memory formation in neocortex.

引用

页码：1050 / 1075

页数：26

共 294 条

[31] Sleep-wake cycles drive daily dynamics of synaptic phosphorylation [J].