Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Subvariant Neutralization Following a Primary Vaccine Series of NVX-CoV2373 and BNT162b2 Monovalent Booster Vaccine

被引：2

作者：

Babu, Tara M. ^{[1
,11
]}

Shen, Xiaoying ^{[2
]}

Mcclelland, R. Scott ^{[1
,3
,4
]}

Wang, Zijun ^{[5
]}

Selke, Stacy ^{[1
]}

Wilkens, Chloe ^{[1
]}

Hauge, Kirsten A. ^{[1
]}

Mcclurkan, Christopher L. ^{[1
]}

Goecker, Erin ^{[1
]}

Laing, Kerry J. ^{[1
]}

Koelle, David M. ^{[1
,3
,6
,7
,8
]}

Greninger, Alexander L. ^{[6
,7
]}

Nussenzweig, Michel C. ^{[5
,9
]}

Montefiori, David C. ^{[2
,10
]}

Corey, Lawrence ^{[1
,6
,7
]}

Wald, Anna ^{[4
,6
,7
]}

机构：

[1] Univ Washington, Dept Med, Div Allergy & Infect Dis, Seattle, WA USA

[2] Duke Univ, Med Ctr, Dept Surg, Durham, NC USA

[3] Univ Washington, Dept Global Hlth, Seattle, WA USA

[4] Univ Washington, Dept Epidemiol, Seattle, WA USA

[5] Rockefeller Univ, Lab Mol Immunol, New York, NY USA

[6] Univ Washington, Dept Lab Med & Pathol, Seattle, WA USA

[7] Fred Hutchinson Canc Ctr, Vaccine & Infect Dis Div, Seattle, WA USA

[8] Benaroya Res Inst, Seattle, WA USA

[9] Rockefeller Univ, Howard Hughes Med Inst, New York, NY USA

[10] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC USA

[11] Univ Washington, Dept Med, Div Allergy & Infect Dis, 908 Jefferson St,11NJB1166, Seattle, WA 98104 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2024年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

antibody; SARS-CoV-2; vaccine; virus;

D O I：

10.1093/ofid/ofad673

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the immunologic response to a novel vaccine regimen that included 2 doses of NVX-CoV2373 (Novavax) followed by 1 dose of BNT162b2 (Pfizer-BioNTech) monovalent booster vaccine. A durable neutralizing antibody response to Omicron BA.4/BA.5 and BA.1 variants was observed at month 6 after the booster, while immune escape was noted for the XBB.1.5 variant.

引用

页数：4

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