Diverse terpenoid glycosides with in vitro cytotoxicity from Glechoma longituba

被引：1

作者：

Yuan, Ming-Ming ^{[1
]}

Xu, Fang ^{[2
]}

Zheng, Yang-Bing ^{[1
]}

Zhou, Lei-Gang ^{[1
]}

Deng, Yu ^{[1
]}

Zhou, Guo-Ping ^{[1
]}

Wu, Xi ^{[1
]}

Ji, Teng-Fei ^{[2
,3
]}

机构：

[1] Jiangxi Inst Drug Control, Jiangxi Prov Engn Res Ctr Drug & Med Device Qual, NMPA Key Lab Qual Evaluat Tradit Chinese Patent Me, Nanchang 330029, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

[3] Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810008, Peoples R China

来源：

PHYTOCHEMISTRY | 2024年 / 217卷

关键词：

Glechoma longituba; Lamiaceae; Terpenoid glycoside; Diterpenoid glycoside; Pentacyclic triterpenoid saponin; Cytotoxic activity; BIOSYNTHESIS; DITERPENOIDS;

D O I：

10.1016/j.phytochem.2023.113923

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Terpenoids are the largest class of all known natural products, possessing structural diversity and numerous biological activities. Ten previously undescribed terpenoid glycosides, glechlongsides A-J (1-10), were isolated from the ethanol extract of the whole plant of Glechoma longituba, including diterpenoid glycoside and penta-cyclic triterpenoid saponin. The structures of these compounds were characterized by extensive analysis of 1D and 2D NMR as well as HRESIMS spectra. In addition, glechlongsides F-I (6-9) exhibited weak cytotoxicity against human cancer cell lines BGC-823, Be1, HCT-8, A2780, and A549 with IC50 values ranging from 3.77 to 30.95 mu M, respectively.

引用

页数：9

共 24 条

[1] Glechoma hederacea inhibits inflammatory mediator release in IFN-γ and LPS-stimulated mouse peritoneal macrophages [J].