Lewis acid-promoted direct synthesis of isoxazole derivatives

被引：1

作者：

Qiu, Dengxu ^{[1
]}

Jiang, Chenhui ^{[1
]}

Gao, Pan ^{[1
]}

Yuan, Yu ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 19卷

关键词：

aluminum trichloride; Lewis acid; isoxazole derivatives; sodium nitrite; transition metals; BOND OXIDATIVE FUNCTIONALIZATION; CLEAVAGE; NITRITE; ARYL;

D O I：

10.3762/bjoc.19.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.

引用

页码：1562 / 1567

页数：6

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