Synthesis of New Fused 3(4)-Substituted 11-Furylthieno[3,2-d]pyrimidine Derivatives

被引：0

作者：

Dabaeva, V. V. ^{[1
]}

Baghdasaryan, M. R. ^{[1
]}

Barkhudaryants, I. M. ^{[1
]}

Paronikyan, E. G. ^{[1
]}

Dashyan, Sh. Sh. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 09期

关键词：

thiophene; furan; pyrano[4,3-b]pyridine; thieno[3,2-d]pyrimidine; nucleophilic substitution; NEUROTROPIC ACTIVITY;

D O I：

10.1134/S1070363223090050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method was developed for the synthesis of new fused 3-alkyl-substituted derivatives of thieno[3,2-d]pyrimidin-4(3H)-ones based on 11-(2-furyl)-8,8-dimethyl-7,10-dihydro-8H-pyrano[3 '',4 '':5 ',6 ']pyrido[3 ',2 ':4,5]thieno[3,2-d]pyrimidin-4(3H)-one via nucleophilic substitution in the pyrimidine ring. A series of fused 4-amino-substituted 11-furylthieno[3,2-d]pyrimidine derivatives was also synthesized from the corresponding 4-chloro derivative.

引用

页码：2224 / 2229

页数：6

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