Dibenzo[b,f]oxepine Molecules Used in Biological Systems and Medicine

被引：11

作者：

Krawczyk, Hanna ^{[1
]}

机构：

[1] Warsaw Univ Technol, Fac Chem, Dept Organ Chem, Noakowskiego 3, PL-00664 Warsaw, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期

关键词：

dibenzo[b; f]oxepine derivatives; synthesis; biological data; medical data; ANTIINFLAMMATORY CONSTITUENTS; BAUHINIA-ACURUANA; EXCITED-STATE; DERIVATIVES; ALKALOIDS; ARTOCARPOL; BINDING; ANTIMYCOBACTERIAL; DIBENZOXEPINES; IDENTIFICATION;

D O I：

10.3390/ijms241512066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this short review, including 113 references, issues related to dibenzo[b,f]oxepine derivatives are presented. Dibenzo[b,f]oxepine scaffold is an important framework in medicinal chemistry, and its derivatives occur in several medicinally relevant plants. At the same time, the structure, production, and therapeutic effects of dibenzo[b,f]oxepines have not been extensively discussed thus far and are presented in this review. This manuscript addresses the following issues: extracting dibenzo[b,f]oxepines from plants and its significance in medicine, the biosynthesis of dibenzo[b,f]oxepines, the active synthetic dibenzo[b,f]oxepine derivatives, the potential of dibenzo[b,f]oxepines as microtubule inhibitors, and perspective for applications of dibenzo[b,f]oxepine derivatives. In conclusion, this review describes studies on various structural features and pharmacological actions of dibenzo[b,f]oxepine derivatives.

引用

页数：21

共 116 条

[21] Tournefolic acid B attenuates amyloid β protein-mediated toxicity by abrogating the calcium overload in mitochondria and retarding the caspase 8-truncated Bid-cytochrome c pathway in rat cortical neurons [J].